Characteristics of patients, donors, and transplants
| Characteristic . | MSD-HSCT (n = 30) . | UD-PBSCT (n = 52) . | Total (n = 82) . | P . |
|---|---|---|---|---|
| Categorization of thalassemia | ||||
| Patient age | 0.897 | |||
| Median, range | 6.0 (0.6-13) | 6.0 (2-15) | 6.0 (0.6-15) | |
| Patient sex | ||||
| Male (%) | 20 (66.7) | 36 (69.2) | 56 (68.3) | .810 |
| Female (%) | 10 (33.3) | 16 (30.8) | 26 (31.7) | |
| Donor sex | ||||
| Male (%) | 16 (53.3) | 29 (55.8) | 45 (54.9) | .831 |
| Female (%) | 14 (46.7) | 23 (44.2) | 37 (45.1) | |
| Donor age | ||||
| Median, range | 3 (1-19) | 28 (20-51) | 24 (1-51) | .000 |
| Serum ferritin | ||||
| Median, range | 3252 (233-7198) | 3271.6 (515-8250) | 3252 (233-8250) | .437 |
| Donor/patient ABO-match | ||||
| Match (%) | 20 (66.7) | 18 (34.6) | 38 (46.3) | .005 |
| Mismatch (%) | 10 (33.3) | 34 (65.4) | 44 (53.7) | |
| Stem cell source | ||||
| BM (%) | 14 (46.7) | 0 (0) | 14 (17.1) | .000 |
| PBSC (%) | 4 (13.3) | 52 (100) | 56 (68.3) | |
| BM + UCB (%) | 12 (40.0) | 0 (0) | 12 (14.6) | |
| HLA matching status | .007 | |||
| 8/8 of the HLA-A, HLA-B, HLA-C, and HLA-DRB1 loci are matched (%) | 28 (93.3) | 32 (61.5) | 60 (73.2) | |
| 7/8 matched (%) | 2 (6.7)* | 19 (36.5)† | 21 (25.6) | |
| 6/8 matched (%) | 0 (0) | 1 (2.0)‡ | 1 (1.2) |
| Characteristic . | MSD-HSCT (n = 30) . | UD-PBSCT (n = 52) . | Total (n = 82) . | P . |
|---|---|---|---|---|
| Categorization of thalassemia | ||||
| Patient age | 0.897 | |||
| Median, range | 6.0 (0.6-13) | 6.0 (2-15) | 6.0 (0.6-15) | |
| Patient sex | ||||
| Male (%) | 20 (66.7) | 36 (69.2) | 56 (68.3) | .810 |
| Female (%) | 10 (33.3) | 16 (30.8) | 26 (31.7) | |
| Donor sex | ||||
| Male (%) | 16 (53.3) | 29 (55.8) | 45 (54.9) | .831 |
| Female (%) | 14 (46.7) | 23 (44.2) | 37 (45.1) | |
| Donor age | ||||
| Median, range | 3 (1-19) | 28 (20-51) | 24 (1-51) | .000 |
| Serum ferritin | ||||
| Median, range | 3252 (233-7198) | 3271.6 (515-8250) | 3252 (233-8250) | .437 |
| Donor/patient ABO-match | ||||
| Match (%) | 20 (66.7) | 18 (34.6) | 38 (46.3) | .005 |
| Mismatch (%) | 10 (33.3) | 34 (65.4) | 44 (53.7) | |
| Stem cell source | ||||
| BM (%) | 14 (46.7) | 0 (0) | 14 (17.1) | .000 |
| PBSC (%) | 4 (13.3) | 52 (100) | 56 (68.3) | |
| BM + UCB (%) | 12 (40.0) | 0 (0) | 12 (14.6) | |
| HLA matching status | .007 | |||
| 8/8 of the HLA-A, HLA-B, HLA-C, and HLA-DRB1 loci are matched (%) | 28 (93.3) | 32 (61.5) | 60 (73.2) | |
| 7/8 matched (%) | 2 (6.7)* | 19 (36.5)† | 21 (25.6) | |
| 6/8 matched (%) | 0 (0) | 1 (2.0)‡ | 1 (1.2) |
One antigenic mismatch at the HLA-A locus and 1 antigenic mismatch at the HLA-DRB1 locus.
Allelic mismatches occurred at the HLA-A locus in 7 donor-recipient pairs, at the HLA-DRB1 locus in 9 donor-recipient pairs, at the HLA-C locus in 2 donor-recipient pair, and at the HLA-B locus in 1 donor-recipient pair.
Allelic mismatches at both the HLA-C and the HLA-DRB1 loci occurred in 1 donor-recipient pair.