Top 10 up- and down-regulated genes per subset
| Top 10 genes up-regulated in: . | Top 10 genes down-regulated in: . | ||||||
|---|---|---|---|---|---|---|---|
| Gene . | Description . | FC . | P . | Gene . | Description . | FC . | P . |
| HSC | |||||||
| TGFB1I1 | TGF beta 1–induced transcript 1 | 3.00 | .0001 | SKIL | SKI-like oncogene | −8.13 | .000008 |
| MEX3D | mex-3 homolog D (Caenorhabditis elegans) | 2.87 | .0004 | RAD23B | Homolog (Saccharomyces cerevisiae) | −4.46 | .0000009 |
| SOCS3 | Suppressor of cytokine signaling 3 | 2.77 | .0006 | CD44 | CD44 (Indian blood group) | −3.98 | .00001 |
| VWF | von Willebrand factor | 2.70 | .0004 | ATP5C1 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | −3.10 | .00008 |
| UCHL1 | Ubiquitn thiolesterase L1 | 2.56 | .0001 | PSPH | Phosphoserine phosphatase | −3.09 | .0005 |
| PRR16 | Proline-rich 16 | 2.47 | .000005 | ARL17P1 | ADP-ribosylation factor-like 17 pseudogene 1 | −3.00 | .0001 |
| CLU | Clusterin | 2.38 | .00005 | LRRC37A | Leucine-rich repeat contain 37A | −2.86 | .0006 |
| VANGL1 | vang-like 1 (Drosophila) | 2.37 | .0002 | RUFY2 | RUN and FYVE dom. containing 2 | −2.84 | .00003 |
| NBL1 | Neuroblastoma, suppression of tumorigenicity 1 | 2.30 | .00007 | SMEK2 | SMEK homolog 2, suppressor of mek1 (Dictyostelium) | −2.78 | .00008 |
| FLOT2 | flotillin 2 | 2.28 | .0003 | LRP5L | Low-density lipoprotein receptor-related protein 5-like | −2.72 | .0006 |
| CMP | |||||||
| FMO5 | Flavin-containing monooxygenase 5 | 3.06 | .00001 | MME | Membrane metalloendopeptidase | −9.83 | .000008 |
| TSPAN6 | Tetraspanin 6 | 2.77 | .00004 | CD24 | CD24 molecule | −7.70 | .00001 |
| HSPB11 | Heat shock protein family B (small), member 11 | 2.66 | .00006 | AKAP12 | A kinase (PRKA) anchor protein 12 | −6.44 | .000001 |
| MAT2A | Methionine adenosyltransferase II, alpha | 2.48 | .00008 | POU2AF1 | POU class 2–associating factor 1 | −5.93 | .00003 |
| EIF1 | Eukaryotic translation initiation factor 1 | 2.40 | .00005 | RAG2 | Recombination activating gene 2 | −5.19 | .0001 |
| CFH | Complement factor H | 2.34 | .0003 | DNTT | Deoxynucleotidyltransferase, terminal | −4.27 | .0007 |
| TUBD1 | Tubulin, delta 1 | 2.22 | .0003 | RAG1 | Recombination activating gene 1 | −4.24 | .00005 |
| ADORA2B | Adenosine A2b receptor | 2.17 | .0008 | IER3 | Immediate early response 3 | −4.03 | .0006 |
| EGLN3 | egl nine homolog 3 (C elegans) | 2.12 | .00007 | BLNK | B-cell linker | −3.79 | .0007 |
| TXNIP | Thioredoxin-interacting protein | 2.11 | .0005 | S1PR1 | Sphingosine-1-phosphate receptor 1 | −3.29 | .00006 |
| GMP | |||||||
| CHRM3 | Cholinergic receptor, muscarinic 3 | 3.36 | .0004 | MTMR6 | Myotubularin-related protein 6 | −3.68 | .0003 |
| KCNK5 | Potassium channel, subfamily K, member 5 | 3.26 | .0002 | PELI1 | pellino homolog 1 (Drosophila) | −3.31 | .0001 |
| NBL1 | Neuroblastoma, suppression of tumorigenicity 1 | 2.78 | .0002 | RAB11FIP1 | RAB11 family–interacting protein 1 (class I) | −3.22 | .00003 |
| EIF3B | Eukaryotic translation initiation factor 3, subunit B | 2.74 | .0002 | KIF1A | Kinesin family member 1A | −3.15 | .0008 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 2.73 | .0006 | PTPRE | Protein tyrosine phosphatase, receptor type E | −3.00 | .0005 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 2.39 | .00009 | DUSP10 | Dual specificity phosphatase 10 | −2.88 | .0001 |
| LEPR | Leptin receptor | 2.39 | .00007 | YT healthy donors C1 | YTH domain containing 1 | −2.80 | .0003 |
| CLU | Clusterin | 2.38 | .00008 | JMJD1C | jumonji domain containing 1C | −2.79 | .00007 |
| PTPN7 | Protein tyrosine phosphatase, nonreceptor type 7 | 2.23 | .0004 | B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransfer., polypeptide 2 | −2.71 | .0003 |
| UBAP2L | Ubiquitin-associated protein 2-like | 2.20 | .0003 | CDC73 | cell divis. cycle 73, Paf1/RNA pol. II compl. homolog (S cerevisiae) | −2.67 | .0009 |
| MEP | |||||||
| TXNIP | Thioredoxin-interacting protein | 3.95 | .00002 | NIACR2 | Niacin receptor 2 | −5.79 | .0002 |
| TLR3 | Toll-like receptor 3 | 3.87 | .0004 | BLNK | B-cell linker | −4.55 | .0004 |
| VWF | von Willebrand factor | 3.64 | .0002 | ARL4C | ADP-ribosylation factor-like 4C | −4.09 | .00008 |
| STXBP6 | Syntaxin-binding protein 6 | 3.48 | .0004 | BCL6 | B-cell CLL/lymphoma 6 | −4.00 | .0003 |
| CCNF | Cyclin F | 3.22 | .0006 | KIF1A | Kinesin family member 1A | −3.99 | .00001 |
| DLK1 | Delta-like 1 homolog (Drosophila) | 3.16 | .0009 | HERPUD1 | Homocyst.-inducible, ER stress-induce, ubiquitin-like d. member 1 | −3.92 | .0001 |
| VEGFA | Vascular endothelial growth factor A | 3.00 | .00008 | CD44 | CD44 (Indian blood group) | −3.85 | .0001 |
| ZKSCAN1 | Zinc finger with KRAB and SCAN domains 1 | 2.94 | .00005 | DDIT3 | DNA damage–inducible transcript 3 | −3.67 | .0006 |
| MTMR3 | Myotubularin-related protein 3 | 2.91 | .0009 | RBM34 | RNA-binding motif protein 34 | −3.62 | .0001 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 2.85 | .0002 | SMEK1 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | −3.42 | .00002 |
| Top 10 genes up-regulated in: . | Top 10 genes down-regulated in: . | ||||||
|---|---|---|---|---|---|---|---|
| Gene . | Description . | FC . | P . | Gene . | Description . | FC . | P . |
| HSC | |||||||
| TGFB1I1 | TGF beta 1–induced transcript 1 | 3.00 | .0001 | SKIL | SKI-like oncogene | −8.13 | .000008 |
| MEX3D | mex-3 homolog D (Caenorhabditis elegans) | 2.87 | .0004 | RAD23B | Homolog (Saccharomyces cerevisiae) | −4.46 | .0000009 |
| SOCS3 | Suppressor of cytokine signaling 3 | 2.77 | .0006 | CD44 | CD44 (Indian blood group) | −3.98 | .00001 |
| VWF | von Willebrand factor | 2.70 | .0004 | ATP5C1 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | −3.10 | .00008 |
| UCHL1 | Ubiquitn thiolesterase L1 | 2.56 | .0001 | PSPH | Phosphoserine phosphatase | −3.09 | .0005 |
| PRR16 | Proline-rich 16 | 2.47 | .000005 | ARL17P1 | ADP-ribosylation factor-like 17 pseudogene 1 | −3.00 | .0001 |
| CLU | Clusterin | 2.38 | .00005 | LRRC37A | Leucine-rich repeat contain 37A | −2.86 | .0006 |
| VANGL1 | vang-like 1 (Drosophila) | 2.37 | .0002 | RUFY2 | RUN and FYVE dom. containing 2 | −2.84 | .00003 |
| NBL1 | Neuroblastoma, suppression of tumorigenicity 1 | 2.30 | .00007 | SMEK2 | SMEK homolog 2, suppressor of mek1 (Dictyostelium) | −2.78 | .00008 |
| FLOT2 | flotillin 2 | 2.28 | .0003 | LRP5L | Low-density lipoprotein receptor-related protein 5-like | −2.72 | .0006 |
| CMP | |||||||
| FMO5 | Flavin-containing monooxygenase 5 | 3.06 | .00001 | MME | Membrane metalloendopeptidase | −9.83 | .000008 |
| TSPAN6 | Tetraspanin 6 | 2.77 | .00004 | CD24 | CD24 molecule | −7.70 | .00001 |
| HSPB11 | Heat shock protein family B (small), member 11 | 2.66 | .00006 | AKAP12 | A kinase (PRKA) anchor protein 12 | −6.44 | .000001 |
| MAT2A | Methionine adenosyltransferase II, alpha | 2.48 | .00008 | POU2AF1 | POU class 2–associating factor 1 | −5.93 | .00003 |
| EIF1 | Eukaryotic translation initiation factor 1 | 2.40 | .00005 | RAG2 | Recombination activating gene 2 | −5.19 | .0001 |
| CFH | Complement factor H | 2.34 | .0003 | DNTT | Deoxynucleotidyltransferase, terminal | −4.27 | .0007 |
| TUBD1 | Tubulin, delta 1 | 2.22 | .0003 | RAG1 | Recombination activating gene 1 | −4.24 | .00005 |
| ADORA2B | Adenosine A2b receptor | 2.17 | .0008 | IER3 | Immediate early response 3 | −4.03 | .0006 |
| EGLN3 | egl nine homolog 3 (C elegans) | 2.12 | .00007 | BLNK | B-cell linker | −3.79 | .0007 |
| TXNIP | Thioredoxin-interacting protein | 2.11 | .0005 | S1PR1 | Sphingosine-1-phosphate receptor 1 | −3.29 | .00006 |
| GMP | |||||||
| CHRM3 | Cholinergic receptor, muscarinic 3 | 3.36 | .0004 | MTMR6 | Myotubularin-related protein 6 | −3.68 | .0003 |
| KCNK5 | Potassium channel, subfamily K, member 5 | 3.26 | .0002 | PELI1 | pellino homolog 1 (Drosophila) | −3.31 | .0001 |
| NBL1 | Neuroblastoma, suppression of tumorigenicity 1 | 2.78 | .0002 | RAB11FIP1 | RAB11 family–interacting protein 1 (class I) | −3.22 | .00003 |
| EIF3B | Eukaryotic translation initiation factor 3, subunit B | 2.74 | .0002 | KIF1A | Kinesin family member 1A | −3.15 | .0008 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 2.73 | .0006 | PTPRE | Protein tyrosine phosphatase, receptor type E | −3.00 | .0005 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 2.39 | .00009 | DUSP10 | Dual specificity phosphatase 10 | −2.88 | .0001 |
| LEPR | Leptin receptor | 2.39 | .00007 | YT healthy donors C1 | YTH domain containing 1 | −2.80 | .0003 |
| CLU | Clusterin | 2.38 | .00008 | JMJD1C | jumonji domain containing 1C | −2.79 | .00007 |
| PTPN7 | Protein tyrosine phosphatase, nonreceptor type 7 | 2.23 | .0004 | B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransfer., polypeptide 2 | −2.71 | .0003 |
| UBAP2L | Ubiquitin-associated protein 2-like | 2.20 | .0003 | CDC73 | cell divis. cycle 73, Paf1/RNA pol. II compl. homolog (S cerevisiae) | −2.67 | .0009 |
| MEP | |||||||
| TXNIP | Thioredoxin-interacting protein | 3.95 | .00002 | NIACR2 | Niacin receptor 2 | −5.79 | .0002 |
| TLR3 | Toll-like receptor 3 | 3.87 | .0004 | BLNK | B-cell linker | −4.55 | .0004 |
| VWF | von Willebrand factor | 3.64 | .0002 | ARL4C | ADP-ribosylation factor-like 4C | −4.09 | .00008 |
| STXBP6 | Syntaxin-binding protein 6 | 3.48 | .0004 | BCL6 | B-cell CLL/lymphoma 6 | −4.00 | .0003 |
| CCNF | Cyclin F | 3.22 | .0006 | KIF1A | Kinesin family member 1A | −3.99 | .00001 |
| DLK1 | Delta-like 1 homolog (Drosophila) | 3.16 | .0009 | HERPUD1 | Homocyst.-inducible, ER stress-induce, ubiquitin-like d. member 1 | −3.92 | .0001 |
| VEGFA | Vascular endothelial growth factor A | 3.00 | .00008 | CD44 | CD44 (Indian blood group) | −3.85 | .0001 |
| ZKSCAN1 | Zinc finger with KRAB and SCAN domains 1 | 2.94 | .00005 | DDIT3 | DNA damage–inducible transcript 3 | −3.67 | .0006 |
| MTMR3 | Myotubularin-related protein 3 | 2.91 | .0009 | RBM34 | RNA-binding motif protein 34 | −3.62 | .0001 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 2.85 | .0002 | SMEK1 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | −3.42 | .00002 |
FC indicates fold change.