Selection of consistently deregulated pathways in HSC, CMP, MEP, and GMP
| Functional group/pathway |
| Organization of the cytoskeleton, adhesion, and motility |
| Y branching of actin filaments |
| Role of PI3K subunit p85 in regulation of actin organization and cell migration |
| Role of MAL in Rho-mediated activation of srf |
| Signaling pathway from G-protein families |
| M-calpain and friends in cell motility |
| Integrin signaling pathway |
| Cell-to-cell adhesion signaling |
| Cell-cycle regulation and proliferation |
| Cell cycle: G1/S check point |
| Cell-cycle G2/M checkpoint |
| Cyclins and cell-cycle regulation |
| Influence of Ras and Rho proteins on G1 to S transition |
| Inhibition of cellular proliferation by gleevec |
| Regulation of cell-cycle progression by Plk3 |
| Cell-signaling cascades |
| AKT signaling pathway |
| ERK1/2 MAPK signaling pathway |
| Growth hormone signaling pathway |
| NF-κB signaling pathway |
| p38 MAPK signaling pathway |
| Ras signaling pathway |
| TGF beta signaling pathway |
| TNFR 1 signaling pathway |
| Miscellaneous |
| Bone remodeling |
| EPO signaling pathway |
| Hypoxia and p53 in the cardiovascular system |
| HIF in the cardiovascular system |
| Oxidative stress-induced gene expression via Nrf2 |
| Telomeres, telomerase cellular aging, and immortality |
| VEGF hypoxia and angiogenesis |
| Functional group/pathway |
| Organization of the cytoskeleton, adhesion, and motility |
| Y branching of actin filaments |
| Role of PI3K subunit p85 in regulation of actin organization and cell migration |
| Role of MAL in Rho-mediated activation of srf |
| Signaling pathway from G-protein families |
| M-calpain and friends in cell motility |
| Integrin signaling pathway |
| Cell-to-cell adhesion signaling |
| Cell-cycle regulation and proliferation |
| Cell cycle: G1/S check point |
| Cell-cycle G2/M checkpoint |
| Cyclins and cell-cycle regulation |
| Influence of Ras and Rho proteins on G1 to S transition |
| Inhibition of cellular proliferation by gleevec |
| Regulation of cell-cycle progression by Plk3 |
| Cell-signaling cascades |
| AKT signaling pathway |
| ERK1/2 MAPK signaling pathway |
| Growth hormone signaling pathway |
| NF-κB signaling pathway |
| p38 MAPK signaling pathway |
| Ras signaling pathway |
| TGF beta signaling pathway |
| TNFR 1 signaling pathway |
| Miscellaneous |
| Bone remodeling |
| EPO signaling pathway |
| Hypoxia and p53 in the cardiovascular system |
| HIF in the cardiovascular system |
| Oxidative stress-induced gene expression via Nrf2 |
| Telomeres, telomerase cellular aging, and immortality |
| VEGF hypoxia and angiogenesis |
All pathways shown were significantly deregulated in HSC, CMP, GMP, and MEP. Pathways were considered significantly deregulated with a P value < .05.
HSC indicates hematopoietic stem cell; MEP, megakaryocyte-erythroid progenitor; CMP, common myeloid progenitor; and GMP, granulocyte-monocyte progenitor.