Table 2

Distribution of HMOX1 polymorphisms and α-globin gene deletion status among 942 children in the SIT Trial by genotype and allele class

−413A > T (rs2071746)
(GT)n(rs3074372): S/L
α-globin status
Genotype*%Genotype†%Genotype‡%
AA 11.6 S/S 3.7 αα/αα 58.2 
AT 42.1 S/L 25.2 −α/αα 36.6 
TT 46.3 L/L 71.1 −α/-α 5.2 
−413A > T (rs2071746)
(GT)n(rs3074372): S/L
α-globin status
Genotype*%Genotype†%Genotype‡%
AA 11.6 S/S 3.7 αα/αα 58.2 
AT 42.1 S/L 25.2 −α/αα 36.6 
TT 46.3 L/L 71.1 −α/-α 5.2 
*

−413A > T results are in Hardy-Weinberg equilibrium (P = .369).

†

(GT)n allele classes defined by number of repeats: S ≤ 25 repeats; and L > 25 repeats.

‡

Persons with αα/ααα genotypes carried no gene deletions and were grouped with αα/αα.

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