Pearson correlation coefficient (ρ)–defined association of stroma-altered expression of CXCR4 with changes in intracellular mTOR signaling in 9 pairs of cocultured primary AML cells and MSCs
| Intracellular signaling (N = 9) . | CXCR4 in attached MSCs . | CXCR4 in attached CD34+ cells . | CXCR4 in attached leukemic cells . | |||
|---|---|---|---|---|---|---|
| ρ . | P . | ρ . | P . | ρ . | P . | |
| p4EPB1 (TORC1) | 0.999 | < .001 | 0.724 | .0275 | 0.768 | .0157 |
| pS6K (TORC1) | 0.999 | < .001 | 0.123 | > .05 | 0.232 | > .05 |
| pAKT (TORC2) | 0.995 | < .001 | 0.687 | .0407 | 0.656 | > .05 |
| Intracellular signaling (N = 9) . | CXCR4 in attached MSCs . | CXCR4 in attached CD34+ cells . | CXCR4 in attached leukemic cells . | |||
|---|---|---|---|---|---|---|
| ρ . | P . | ρ . | P . | ρ . | P . | |
| p4EPB1 (TORC1) | 0.999 | < .001 | 0.724 | .0275 | 0.768 | .0157 |
| pS6K (TORC1) | 0.999 | < .001 | 0.123 | > .05 | 0.232 | > .05 |
| pAKT (TORC2) | 0.995 | < .001 | 0.687 | .0407 | 0.656 | > .05 |
Raw and adjusted P values were calculated as described in “Flow cytometry.”