Second procedures
| Age, mo . | Time of event posttransplant, mo . | High-risk features . | Conditioning . | CD34/kg body weight (×106) . | Stem cell source . | Donor . | Type of event . | Reason . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|
| 14 | 2 | Y | Treo Cy A | 5.00 | PBSC | MUD | Top up | Decreasing donor chimerism | Alive, 100% chimerism |
| 37 | 18 | Y | Treo Flu A | 10.10 | PBSC | MUD | Second HCT: Bu/Flu | Decreasing donor chimerism | Alive, 100% chimerism |
| 47 | 3 | Y | Treo Flu A | 2.34 | BM | URD 9/10 | DLI ×3 + second HCT: 9/10 Cord, Bu/Flu | Decreasing donor chimerism (0%) | Alive, 100% chimerism |
| 63 | 46 | Y | Treo Flu A | 6.10 | BM | URD 9/10 | Second HCT: Bu/Flu | Decreasing donor chimerism | Alive. Stable donor chimerism |
| 128 | 23 | Y | Treo Flu A | 16.00 | PBSC | MUD | Top up | Pancytopenia with hypocellular marrow | Deceased |
| 132 | 5 | Y | Treo Flu TT A | 10.00 | PBSC | MUD | DLI ×3 + second HCT: Same donor Bu/Flu | Decreasing donor chimerism (20%) | Alive, 100% chimerism |
| 141 | 7 | Y | Treo Flu A | 7.65 | PBSC | MUD | Second HCT: Same donor Bu/Flu | Decreasing donor chimerism | Alive, stable donor chimerism |
| 145 | 7 | Y | Treo Flu TT ATG | 3.40 | BM | URD 9/10 | DLI ×5 | Decreasing donor chimerism | Alive, decreasing donor chimerism (CD15, 20%-40%; CD3, 70%-80%) |
| Age, mo . | Time of event posttransplant, mo . | High-risk features . | Conditioning . | CD34/kg body weight (×106) . | Stem cell source . | Donor . | Type of event . | Reason . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|
| 14 | 2 | Y | Treo Cy A | 5.00 | PBSC | MUD | Top up | Decreasing donor chimerism | Alive, 100% chimerism |
| 37 | 18 | Y | Treo Flu A | 10.10 | PBSC | MUD | Second HCT: Bu/Flu | Decreasing donor chimerism | Alive, 100% chimerism |
| 47 | 3 | Y | Treo Flu A | 2.34 | BM | URD 9/10 | DLI ×3 + second HCT: 9/10 Cord, Bu/Flu | Decreasing donor chimerism (0%) | Alive, 100% chimerism |
| 63 | 46 | Y | Treo Flu A | 6.10 | BM | URD 9/10 | Second HCT: Bu/Flu | Decreasing donor chimerism | Alive. Stable donor chimerism |
| 128 | 23 | Y | Treo Flu A | 16.00 | PBSC | MUD | Top up | Pancytopenia with hypocellular marrow | Deceased |
| 132 | 5 | Y | Treo Flu TT A | 10.00 | PBSC | MUD | DLI ×3 + second HCT: Same donor Bu/Flu | Decreasing donor chimerism (20%) | Alive, 100% chimerism |
| 141 | 7 | Y | Treo Flu A | 7.65 | PBSC | MUD | Second HCT: Same donor Bu/Flu | Decreasing donor chimerism | Alive, stable donor chimerism |
| 145 | 7 | Y | Treo Flu TT ATG | 3.40 | BM | URD 9/10 | DLI ×5 | Decreasing donor chimerism | Alive, decreasing donor chimerism (CD15, 20%-40%; CD3, 70%-80%) |
A, alemtuzumab; BM, bone marrow; Bu, busulfan; Cy, cyclophosphamide; DLI, donor lymphocyte infusion; Flu, fludarabine; MUD, matched unrelated donor; PBSC, peripheral blood stem cells; Treo, treosulfan; TT, thiotepa; URD, unrelated donor transplant.