Plasma concentrations of ALX-0681 in animals of the preventive (D3-D6) and therapeutic (C4-C7) study groups
| d . | Calculated plasma concentration of ALX-0681, ng/mL . | |||||||
|---|---|---|---|---|---|---|---|---|
| Animal . | ||||||||
| D3 . | D4 . | D5 . | D6 . | C4 . | C5 . | C6 . | C7 . | |
| 1 | 32.46 | BQL | BQL | BQL | BQL | ND | ND | ND |
| 2 | 170.97 | 150.03 | 308.16 | 231.94 | BQL | ND | ND | ND |
| 3 | 161.14 | 134.31 | 263.78 | 180.57 | BQL | ND | ND | ND |
| 4 | 169.69 | 135.66 | 189.68 | 170.01 | BQL | ND | ND | ND |
| 5 | 165.41 | 156.76 | 222.44 | 188.99 | BQL | ND | ND | ND |
| 6 | ND | ND | ND | ND | 407.37 | 257.15 | 271.84 | 246.37 |
| 7 | 81.45 | 82.06 | 129.64 | 99.05 | 310.89 | 155.87 | 204.31 | 176.11 |
| 8 | ND | ND | ND | ND | 324.30 | 179.62 | 266.17 | 209.12 |
| 9 | 26.23 | BQL | 55.06 | 47.57 | 253.21 | 172.01 | 230.45 | 209.25 |
| 10 | ND | ND | ND | ND | 258.37 | 145.34 | 235.66 | 231.66 |
| 11 | BQL | BQL | BQL | BQL | 286.81 | 151.96 | 210.20 | 201.96 |
| d . | Calculated plasma concentration of ALX-0681, ng/mL . | |||||||
|---|---|---|---|---|---|---|---|---|
| Animal . | ||||||||
| D3 . | D4 . | D5 . | D6 . | C4 . | C5 . | C6 . | C7 . | |
| 1 | 32.46 | BQL | BQL | BQL | BQL | ND | ND | ND |
| 2 | 170.97 | 150.03 | 308.16 | 231.94 | BQL | ND | ND | ND |
| 3 | 161.14 | 134.31 | 263.78 | 180.57 | BQL | ND | ND | ND |
| 4 | 169.69 | 135.66 | 189.68 | 170.01 | BQL | ND | ND | ND |
| 5 | 165.41 | 156.76 | 222.44 | 188.99 | BQL | ND | ND | ND |
| 6 | ND | ND | ND | ND | 407.37 | 257.15 | 271.84 | 246.37 |
| 7 | 81.45 | 82.06 | 129.64 | 99.05 | 310.89 | 155.87 | 204.31 | 176.11 |
| 8 | ND | ND | ND | ND | 324.30 | 179.62 | 266.17 | 209.12 |
| 9 | 26.23 | BQL | 55.06 | 47.57 | 253.21 | 172.01 | 230.45 | 209.25 |
| 10 | ND | ND | ND | ND | 258.37 | 145.34 | 235.66 | 231.66 |
| 11 | BQL | BQL | BQL | BQL | 286.81 | 151.96 | 210.20 | 201.96 |
BQL indicates below the quantification limit of 20 ng/mL; and ND, not determined.