Occlusion scores for all organs
| Organ . | Animal . | |||||
|---|---|---|---|---|---|---|
| C4 . | C5 . | C6 . | C7 . | Mean (C4-C7) . | D10 . | |
| CD61-rich occlusion scores, % | ||||||
| Kidney | 0 | 0 | 0 | 10 | 2.5 | 0 |
| Spleen | 0 | 0 | 0 | 0 | 0 | 0 |
| Heart | 10 | 10 | 10 | 0 | 7.5 | 10 |
| Lung | 0 | 0 | 0 | 0 | 0 | 0 |
| Brain | 20 | 40 | 50 | 40 | 37.5 | 40 |
| VWF-rich occlusion scores, % | ||||||
| Kidney | 0 | 0 | 0 | 10 | 2.5 | 0 |
| Spleen | 0 | 0 | 0 | 10 | 2.5 | 0 |
| Heart | 20 | 20 | 0 | 0 | 10 | 20 |
| Lung | 0 | 0 | 0 | 0 | 0 | 0 |
| Brain | 20 | 30 | 60 | 50 | 40 | 20 |
| Organ . | Animal . | |||||
|---|---|---|---|---|---|---|
| C4 . | C5 . | C6 . | C7 . | Mean (C4-C7) . | D10 . | |
| CD61-rich occlusion scores, % | ||||||
| Kidney | 0 | 0 | 0 | 10 | 2.5 | 0 |
| Spleen | 0 | 0 | 0 | 0 | 0 | 0 |
| Heart | 10 | 10 | 10 | 0 | 7.5 | 10 |
| Lung | 0 | 0 | 0 | 0 | 0 | 0 |
| Brain | 20 | 40 | 50 | 40 | 37.5 | 40 |
| VWF-rich occlusion scores, % | ||||||
| Kidney | 0 | 0 | 0 | 10 | 2.5 | 0 |
| Spleen | 0 | 0 | 0 | 10 | 2.5 | 0 |
| Heart | 20 | 20 | 0 | 0 | 10 | 20 |
| Lung | 0 | 0 | 0 | 0 | 0 | 0 |
| Brain | 20 | 30 | 60 | 50 | 40 | 20 |
Organs were examined for occluded vessels rich in platelets (monoclonal mouse anti–human CD61) or VWF (polyclonal rabbit anti–human VWF). Ten random consecutive vessels were scored for occlusions in animals from the therapeutic study group (C4-C7) and 1 control animal (D10). Results are represented as the percentage of positive vessels. Mean (C4-C7) represents the average occlusion (%) per organ of the 4 animals in the therapeutic study group.