Multivariate analysis of the 3 biologic factors and the IPI in the training set of patients with DLBCL
| . | Overall survival . | Event-free survival . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Choi algorithm | ||||||
| Non-GCB | 2.1 | 1.0-4.4 | .056 | 2.0 | 1.1-3.9 | .033 |
| SPARC+ cells | ||||||
| < 5 % | 2.2 | 1.1-4.5 | .03 | 1.8 | 1.0-3.2 | .068 |
| Microvascular density | ||||||
| Quartile 4 | 2.8 | 1.4-5.8 | .0043 | 2.6 | 1.4-5.0 | .0026 |
| IPI score | ||||||
| High (3-5) | 2.6 | 1.3-5.2 | .0066 | 2.0 | 1.1-3.6 | .027 |
| . | Overall survival . | Event-free survival . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Choi algorithm | ||||||
| Non-GCB | 2.1 | 1.0-4.4 | .056 | 2.0 | 1.1-3.9 | .033 |
| SPARC+ cells | ||||||
| < 5 % | 2.2 | 1.1-4.5 | .03 | 1.8 | 1.0-3.2 | .068 |
| Microvascular density | ||||||
| Quartile 4 | 2.8 | 1.4-5.8 | .0043 | 2.6 | 1.4-5.0 | .0026 |
| IPI score | ||||||
| High (3-5) | 2.6 | 1.3-5.2 | .0066 | 2.0 | 1.1-3.6 | .027 |
IPI indicates International Prognostic Index; DLBCL, diffuse large B-cell lymphoma; CI, confidence interval; GCB, germinal center B-cell-like; and SPARC, secreted protein, acidic, and rich in cysteine.