Univariate analysis of the three biologic factors and the IPI in the training set of patients with DLBCL
| . | Overall survival . | Event-free survival . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Choi algorithm | ||||||
| GCB | 1.0 | .0036 | 1.0 | .0021 | ||
| Non-GCB | 2.5 | 1.3-4.9 | 2.4 | 1.3-4.1 | ||
| SPARC+ cells | ||||||
| ≥ 5 % | 1.0 | .014 | 1.0 | .041 | ||
| < 5 % | 2.1 | 1.1-3.9 | 1.7 | 1.0-3.0 | ||
| Microvascular density | ||||||
| Quartiles 1-3 | 1.0 | .0013 | 1.0 | .0011 | ||
| Quartile 4 | 2.7 | 1.4-5.0 | 2.5 | 1.4-4.3 | ||
| IPI score | ||||||
| Low (0-2) | 1.0 | .0023 | 1.0 | .011 | ||
| High (3-5) | 2.9 | 1.5-5.8 | 2.2 | 1.2-4.0 | ||
| . | Overall survival . | Event-free survival . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Choi algorithm | ||||||
| GCB | 1.0 | .0036 | 1.0 | .0021 | ||
| Non-GCB | 2.5 | 1.3-4.9 | 2.4 | 1.3-4.1 | ||
| SPARC+ cells | ||||||
| ≥ 5 % | 1.0 | .014 | 1.0 | .041 | ||
| < 5 % | 2.1 | 1.1-3.9 | 1.7 | 1.0-3.0 | ||
| Microvascular density | ||||||
| Quartiles 1-3 | 1.0 | .0013 | 1.0 | .0011 | ||
| Quartile 4 | 2.7 | 1.4-5.0 | 2.5 | 1.4-4.3 | ||
| IPI score | ||||||
| Low (0-2) | 1.0 | .0023 | 1.0 | .011 | ||
| High (3-5) | 2.9 | 1.5-5.8 | 2.2 | 1.2-4.0 | ||
IPI indicates International Prognostic Index; DLBCL, diffuse large B-cell lymphoma; CI, confidence interval; GCB, germinal center B cell–like; and SPARC, secreted protein, acidic, and rich in cysteine.