Table 3. Etiology of febrile events .... | American Society of Hematology

Table 3.

Etiology of febrile events

	Hydroxyurea, N = 96			Placebo, N = 97			Hazard ratio†	P†
	Events	Incidence rate*	Subjects, n (%)	Events	Incidence rate*	Subjects, n (%)	Hazard ratio†	P†
Fever	352	186.2	86 (90)	402	217.4	88 (91)	0.89	.5
Aplastic crisis, parvovirus	4	2.1	4 (4)	4	2.2	4 (4)	0.96	1
Acute osteomyelitis	0	0	0	2	1.1	2 (2)	—	.2
Bacteremia/sepsis/meningitis	3	1.6	2 (2)	6	3.2	5 (5)	0.40	.3
Viral syndrome	41	21.7	30 (31)	48	26.0	31 (32)	0.92	.7
Gastroenteritis	70	37.1	44 (46)	69	37.3	45 (46)	0.91	.7
Otitis media	76	40.3	36 (38)	99	53.5	45 (46)	0.73	.2

	Hydroxyurea, N = 96			Placebo, N = 97			Hazard ratio†	P†
	Events	Incidence rate*	Subjects, n (%)	Events	Incidence rate*	Subjects, n (%)	Hazard ratio†	P†
Fever	352	186.2	86 (90)	402	217.4	88 (91)	0.89	.5
Aplastic crisis, parvovirus	4	2.1	4 (4)	4	2.2	4 (4)	0.96	1
Acute osteomyelitis	0	0	0	2	1.1	2 (2)	—	.2
Bacteremia/sepsis/meningitis	3	1.6	2 (2)	6	3.2	5 (5)	0.40	.3
Viral syndrome	41	21.7	30 (31)	48	26.0	31 (32)	0.92	.7
Gastroenteritis	70	37.1	44 (46)	69	37.3	45 (46)	0.91	.7
Otitis media	76	40.3	36 (38)	99	53.5	45 (46)	0.73	.2

Per 100 patient-years.

The hazard ratio (hydroxyurea vs placebo) was generated from a Cox model and the P value from the log-rank life test to compare the time to first event between the two treatment groups.