Genes overexpressed in treatment failure according to function and canonical pathways (Ingenuity Pathway Analysis)
. | P (adjusted) . | Molecules . |
---|---|---|
Function | ||
Developmental process of hematopoietic progenitor cells | .0122 | GATA1, GATA2, WT1, CCND2, TNFRSF11A, CSF1R, IL6ST, INHBA, IRF8 |
Developmental process of mononuclear leukocytes | .0002 | TGFBR2, NFATC1, TNFRSF11A, TNFRSF1A, TNFRSF1B, TNFSF13B, WT1, B4GALNT1, BCL2L11, C3, CSF1R, EOMES, GATA1, GATA2, INHBA, IRF7, IRF8, ITGA4, LAMP1, LTBP1, LTBR, NCAPH2, NPPA, PRDM1, STAP2 |
Migration of macrophages | .0296 | ITGB1, ITGA4, CSF1R, TLR2 |
Developmental process of macrophages | .0462 | CSF1R, PRDM1, TNFRSF1A, INHBA, IRF7, IRF8 |
Development of blood vessel | .0050 | VCAM1, VASH1, SPARC, TGM2, TIMP2, COL18A1, EPHB4, ETV6, GATA2, INHBA, ITGA4, ITGB1, NPR1, PLCD1, QKI, STAB1, TGFBR2, TNFRSF1A, WT1 |
Canonical pathways | ||
NF-κB signaling | .0017 | PDGFRB, TNFRSF11A, TNFRSF1A, TNFRSF1B, TNFSF13B, LTBR, PRKCB, TLR2 |
Role of pattern recognition receptors in recognition of bcteria and viruses | .0003 | IRF7, IRF8, TLR2, OAS1, C3, CASP1, CLEC7A |
Complement system | .0020 | C3, C7, CFD, CFH |
Macropinocytosis | .0044 | ITGB1, ITGB4, PRKCB, CSF1R, ANKFY1 |
. | P (adjusted) . | Molecules . |
---|---|---|
Function | ||
Developmental process of hematopoietic progenitor cells | .0122 | GATA1, GATA2, WT1, CCND2, TNFRSF11A, CSF1R, IL6ST, INHBA, IRF8 |
Developmental process of mononuclear leukocytes | .0002 | TGFBR2, NFATC1, TNFRSF11A, TNFRSF1A, TNFRSF1B, TNFSF13B, WT1, B4GALNT1, BCL2L11, C3, CSF1R, EOMES, GATA1, GATA2, INHBA, IRF7, IRF8, ITGA4, LAMP1, LTBP1, LTBR, NCAPH2, NPPA, PRDM1, STAP2 |
Migration of macrophages | .0296 | ITGB1, ITGA4, CSF1R, TLR2 |
Developmental process of macrophages | .0462 | CSF1R, PRDM1, TNFRSF1A, INHBA, IRF7, IRF8 |
Development of blood vessel | .0050 | VCAM1, VASH1, SPARC, TGM2, TIMP2, COL18A1, EPHB4, ETV6, GATA2, INHBA, ITGA4, ITGB1, NPR1, PLCD1, QKI, STAB1, TGFBR2, TNFRSF1A, WT1 |
Canonical pathways | ||
NF-κB signaling | .0017 | PDGFRB, TNFRSF11A, TNFRSF1A, TNFRSF1B, TNFSF13B, LTBR, PRKCB, TLR2 |
Role of pattern recognition receptors in recognition of bcteria and viruses | .0003 | IRF7, IRF8, TLR2, OAS1, C3, CASP1, CLEC7A |
Complement system | .0020 | C3, C7, CFD, CFH |
Macropinocytosis | .0044 | ITGB1, ITGB4, PRKCB, CSF1R, ANKFY1 |