Function and involved pathways of genes down-regulated in HRS cells (Ingenuity Pathway Analysis)
| . | P (adjusted) . | Molecules . |
|---|---|---|
| Function annotation | ||
| Activation of B lymphocytes | .0005 | CD19, CD22, CD38, CD180, DOK3, IGHG1, INPP5D, POU2AF1, PTPRC, TNFRSF17 |
| Cell death of lymphocytes | .0003 | CASP4, CD27, CDC2, CR2, EZR, ID3, IGF1, IGHM, INPP5D, ITGB1, ITPR3, LCK, MS4A1, NFATC1, PRKCB, PTEN, RAC2, TGFBR2, TNFRSF17 |
| Contact growth inhibition of normal cells | .0031 | HMGB1, LCK, METAP2, PTPRC |
| Antibody response | .0084 | BLNK, HMGB1, IGHG1, LY86, POU2AF1, POU2F2, ST6GAL1 |
| Cell cycle progression | .0014 | ATM, CCDC5, CCNA2, CCNG2, CD19, CDC2, CDC16, CDKN3, CDKN2C, CENPE, CKAP2, CKAP5, CLU, CUL3, DBF4, E2F5, ESR1, FOXO1, HHEX, HPGD, IGF1, IRS1, ITGB1, KAT2B, KIF11, LCK, LRIG1, MAD2L1, PPP2R5C, PRKCD, PTEN, RHOA, RPA1, SMARCA4, SSBP2, SYK, TF, TTN |
| Proliferation of leukocytes | .0026 | BTLA, CD19, CD37, CD38, CD48, CD180, CLECL1, CR1, CR2, FYN, IGF1, IGHG1, IGHM, INPP5D, IRF8, ITGB1, ITK, LCK, MS4A1, PTEN, PTPRC, TCL1A, TIMD4, TNFRSF17 |
| Transcription | .0074 | ATF1, ATM, BACH2, BCOR, BTG2, C19ORF2, CAMK2D, CCNA2, CCNDBP1, CDC2, CDKN2C, CREM, CXORF15, DHX15, E2F5, ELF1, ELK3, ELL3, ESR1, ESRRG, FLI1, FOXO1, HHEX, HMGB1, ID3, IGF1, IL16, ILF2, IRF8, ITGB1, JAZF1, JMJD1C, KAT2B, KLF12, LCK, MALT1, MAML3, MDFIC, MED21, MED30, MEF2C, MYBL1, NFATC1, NFATC3, NFYB, NRIP1, POU2AF1, POU2F2, PPP3CA, PRKACB, PRKAR2B, PRKCB, PRKCD, PTEN, RASA1, RCOR1, REL, RHOA, SET, SMARCA4, SOX8, SP3, SYK, TAF5, TGFBR2, THOC4, TNFRSF17, TOM1L1, TRAF5, VAV3, YWHAZ, ZFP161, ZHX2 |
| Canonical pathways | ||
| B-cell receptor signaling | .0000 | CD19, CD22, CD79A, CD79B, BLNK, SYK, POU2F2, PRKCB, PIK3CG, PIK3CA, PTPRC, CAMK2D, NFATC3, PAG1, RAC2, PPP3CA, NFATC1, INPP5D, RRAS2, VAV3, MALT1, PLCG2, PTEN, PIK3AP1 |
| T-cell receptor signaling | .0000 | LCK, FYN, NFATC1, PIK3CG, PIK3CA, PTPRC, NFATC3, ITK, PAG1, RASA1, PPP3CA, RRAS2, VAV3, MALT1, PTPN7 |
| PDGF signaling | .0062 | PDGFD, PRKCB, INPP5D, PIK3CG, JAK1, RRAS2, PIK3CA, PLCG2, RASA1 |
| Integrin signaling | .0069 | ITGB1, ITGAE, PIK3CG, RHOA, PIK3CA, FYN, RHOH, RHOQ, RAC2, WIPF1, RRAS2, TTN, ARPC3, PLCG2, BCAR3, PTEN |
| Glucocorticoid receptor signaling | .0043 | ESR1, HSPA8, HSP90AB1, NFATC1, NFATC3, HMGB1, PIK3CG, SMARCA4, PIK3CA, KAT2B, HLTF, TAF5, PPP3CA, JAK1, POU2F2, TGFBR2, RRAS2, TAF12, PRKACB, NRIP1 |
| IGF-1 signaling | .0068 | IGF1, RASA1, PIK3CG, RRAS2, YWHAZ, IRS1, FOXO1, PIK3CA, PRKACB, PRKAR2B, |
| Insulin receptor signaling | .0083 | IRS1, JAK1, PTEN, INPP5D, PIK3CG, RRAS2, FOXO1, PIK3CA, PRKACB, PRKAR2B, FYN, RHOQ |
| Chemokine signaling | .0182 | PLCB4, PLCG2, PRKCB, CFL1, PIK3CG, RHOA, RRAS2, CAMK2D |
| . | P (adjusted) . | Molecules . |
|---|---|---|
| Function annotation | ||
| Activation of B lymphocytes | .0005 | CD19, CD22, CD38, CD180, DOK3, IGHG1, INPP5D, POU2AF1, PTPRC, TNFRSF17 |
| Cell death of lymphocytes | .0003 | CASP4, CD27, CDC2, CR2, EZR, ID3, IGF1, IGHM, INPP5D, ITGB1, ITPR3, LCK, MS4A1, NFATC1, PRKCB, PTEN, RAC2, TGFBR2, TNFRSF17 |
| Contact growth inhibition of normal cells | .0031 | HMGB1, LCK, METAP2, PTPRC |
| Antibody response | .0084 | BLNK, HMGB1, IGHG1, LY86, POU2AF1, POU2F2, ST6GAL1 |
| Cell cycle progression | .0014 | ATM, CCDC5, CCNA2, CCNG2, CD19, CDC2, CDC16, CDKN3, CDKN2C, CENPE, CKAP2, CKAP5, CLU, CUL3, DBF4, E2F5, ESR1, FOXO1, HHEX, HPGD, IGF1, IRS1, ITGB1, KAT2B, KIF11, LCK, LRIG1, MAD2L1, PPP2R5C, PRKCD, PTEN, RHOA, RPA1, SMARCA4, SSBP2, SYK, TF, TTN |
| Proliferation of leukocytes | .0026 | BTLA, CD19, CD37, CD38, CD48, CD180, CLECL1, CR1, CR2, FYN, IGF1, IGHG1, IGHM, INPP5D, IRF8, ITGB1, ITK, LCK, MS4A1, PTEN, PTPRC, TCL1A, TIMD4, TNFRSF17 |
| Transcription | .0074 | ATF1, ATM, BACH2, BCOR, BTG2, C19ORF2, CAMK2D, CCNA2, CCNDBP1, CDC2, CDKN2C, CREM, CXORF15, DHX15, E2F5, ELF1, ELK3, ELL3, ESR1, ESRRG, FLI1, FOXO1, HHEX, HMGB1, ID3, IGF1, IL16, ILF2, IRF8, ITGB1, JAZF1, JMJD1C, KAT2B, KLF12, LCK, MALT1, MAML3, MDFIC, MED21, MED30, MEF2C, MYBL1, NFATC1, NFATC3, NFYB, NRIP1, POU2AF1, POU2F2, PPP3CA, PRKACB, PRKAR2B, PRKCB, PRKCD, PTEN, RASA1, RCOR1, REL, RHOA, SET, SMARCA4, SOX8, SP3, SYK, TAF5, TGFBR2, THOC4, TNFRSF17, TOM1L1, TRAF5, VAV3, YWHAZ, ZFP161, ZHX2 |
| Canonical pathways | ||
| B-cell receptor signaling | .0000 | CD19, CD22, CD79A, CD79B, BLNK, SYK, POU2F2, PRKCB, PIK3CG, PIK3CA, PTPRC, CAMK2D, NFATC3, PAG1, RAC2, PPP3CA, NFATC1, INPP5D, RRAS2, VAV3, MALT1, PLCG2, PTEN, PIK3AP1 |
| T-cell receptor signaling | .0000 | LCK, FYN, NFATC1, PIK3CG, PIK3CA, PTPRC, NFATC3, ITK, PAG1, RASA1, PPP3CA, RRAS2, VAV3, MALT1, PTPN7 |
| PDGF signaling | .0062 | PDGFD, PRKCB, INPP5D, PIK3CG, JAK1, RRAS2, PIK3CA, PLCG2, RASA1 |
| Integrin signaling | .0069 | ITGB1, ITGAE, PIK3CG, RHOA, PIK3CA, FYN, RHOH, RHOQ, RAC2, WIPF1, RRAS2, TTN, ARPC3, PLCG2, BCAR3, PTEN |
| Glucocorticoid receptor signaling | .0043 | ESR1, HSPA8, HSP90AB1, NFATC1, NFATC3, HMGB1, PIK3CG, SMARCA4, PIK3CA, KAT2B, HLTF, TAF5, PPP3CA, JAK1, POU2F2, TGFBR2, RRAS2, TAF12, PRKACB, NRIP1 |
| IGF-1 signaling | .0068 | IGF1, RASA1, PIK3CG, RRAS2, YWHAZ, IRS1, FOXO1, PIK3CA, PRKACB, PRKAR2B, |
| Insulin receptor signaling | .0083 | IRS1, JAK1, PTEN, INPP5D, PIK3CG, RRAS2, FOXO1, PIK3CA, PRKACB, PRKAR2B, FYN, RHOQ |
| Chemokine signaling | .0182 | PLCB4, PLCG2, PRKCB, CFL1, PIK3CG, RHOA, RRAS2, CAMK2D |