Function and involved pathways of genes up-regulated in HRS cells (Ingenuity Pathway Analysis)
| . | P (adjusted) . | Molecules . |
|---|---|---|
| Function annotation | ||
| Adhesion of leukocytes | .0002 | CD44, THY1, HGF, IL6, IL15, CCL5, CCL17, CCL19, CCL22, CX3CL1, TXN |
| Apoptosis of eukaryotic cells | .0000 | TNFAIP3, TGFBR3, TNFRSF8, TNFRSF11A, GZMB, WNT2, WT1, TXN, ATF3, B2M, CCL5, CCND2, CD44, CD274, CDKN1A, CRH, CX3CL1, DUSP4, FBXO32, HGF, HOXC6, ID2, IER3, IL6, IL9, IL15, JUN, MAOA, MT2A, MUC1, NFKBIA, NTRK3, PDGFRA, PHLDA1, PLAT, PRAME, RASSF4, RTN1, SOCS3, STAT1, STAT5A, TRA@, |
| Cell surface receptor linked signal transduction | .0003 | IL2RA, PDGFRA, CD274, COL3A1, CX3CL1, CXCL10, IL6, IL31RA, LILRB2, NTRK3, PTPRG |
| Chemotaxis of leukocytes | .0003 | CCL5, CCL8, CCL17, CCL19, CCL22, CCR7, CX3CL1, CXCL10, IL15, SERPINA1, SOCS3, TXN |
| Cytotoxicity of eukaryotic cells | .0008 | GZMB, CX3CL1, CCL5, TXN, IL15, STAT1, TNFAIP3, TNFRSF8, |
| Differentiation of leukocytes | .0000 | TBX21, ID2, JUN, JUNB, TNFRSF11A, RORA, RORC, IL13RA2, IL6, IL9, IL15, IL2RA, TRA@, SOCS3, STAT1, STAT5A |
| Growth of eukaryotic cells | .0000 | CDKN1A, STAT1, STAT5A, TGFBR3, HGF, CRH, CCND2, PTP4A3, PTPRG, NTRK3, ADCY1, ATF3, ATF5, CD44, COL1A1, COL6A3, CXCL10, CYP19A1, DUSP5, FOXC1, GNA15, GZMB, HOXC6, ID2, IER3, IL6, IL9, IL15, IL13RA2, IL1R1, IL2RA, JUN, JUNB, LMNA, MUC1, PCGF2, PRAME, RASSF4, RRAD, SOCS2, SOCS3, TNFRSF8, TXN, WT1 |
| Proliferation of connective tissue cells | .0007 | HGF, CCND2, CD44, CDKN1A, IL6, IL15, PDGFRA, SOCS3 |
| Proliferation of lymphocytes | .0001 | ADRB2, IL2RA, STAT1, STAT5A, CD44, CD274, CDKN1A, TRA@, TRD@, EBI3, IL6, IL15, SERPINA1, THY1 |
| Signaling of cells | .0000 | IL6, IL15, IL26, IL2RA, CCL5, CCL8, CCL17, CCL22, CD97, CXCL10, GJB2, LILRB2, TNFAIP6, TNFRSF11A, TXN |
| Transcription of gene | .0008 | JUN, NFIB, WT1, FOXC1, STAT1, STAT5A, NFKBIA, HGF, AMPH, ASCL1, ATF3, CD44, DUSP4, EHF, IL6, SOCS3 |
| Canonical pathways | ||
| NF-κB signaling | .0005 | TNFRSF11A, PDGFRA, NFKBIA, TNFAIP3, IL1R2, CARD10, TRA@, IL1R1, TRD@, TLR8 |
| JAK/Stat signaling | .0204 | SOCS3, STAT1, STAT5A, CDKN1A, SOCS2 |
| IL-6 signaling | .0010 | IL6, IL1R1, IL1R2, NFKBIA, CYP19A1, JUN, COL1A1, TNFAIP6 |
| IL-9 signaling | .0017 | IL9, SOCS3, STAT1, STAT5A, SOCS2 |
| Cytotoxic T lymphocyte-mediated apoptosis of target cells | .0339 | GZMB, TRA@, TRD@ |
| Hepatic fibrosis/hepatic stellate cell activation | .0005 | HGF, COL1A1, COL3A1, STAT1, IL1R1, CCL5, PDGFRA, CCR7, IL6, IL1R2 |
| IL-15 production | .0437 | IL15, IL6, STAT1 |
| . | P (adjusted) . | Molecules . |
|---|---|---|
| Function annotation | ||
| Adhesion of leukocytes | .0002 | CD44, THY1, HGF, IL6, IL15, CCL5, CCL17, CCL19, CCL22, CX3CL1, TXN |
| Apoptosis of eukaryotic cells | .0000 | TNFAIP3, TGFBR3, TNFRSF8, TNFRSF11A, GZMB, WNT2, WT1, TXN, ATF3, B2M, CCL5, CCND2, CD44, CD274, CDKN1A, CRH, CX3CL1, DUSP4, FBXO32, HGF, HOXC6, ID2, IER3, IL6, IL9, IL15, JUN, MAOA, MT2A, MUC1, NFKBIA, NTRK3, PDGFRA, PHLDA1, PLAT, PRAME, RASSF4, RTN1, SOCS3, STAT1, STAT5A, TRA@, |
| Cell surface receptor linked signal transduction | .0003 | IL2RA, PDGFRA, CD274, COL3A1, CX3CL1, CXCL10, IL6, IL31RA, LILRB2, NTRK3, PTPRG |
| Chemotaxis of leukocytes | .0003 | CCL5, CCL8, CCL17, CCL19, CCL22, CCR7, CX3CL1, CXCL10, IL15, SERPINA1, SOCS3, TXN |
| Cytotoxicity of eukaryotic cells | .0008 | GZMB, CX3CL1, CCL5, TXN, IL15, STAT1, TNFAIP3, TNFRSF8, |
| Differentiation of leukocytes | .0000 | TBX21, ID2, JUN, JUNB, TNFRSF11A, RORA, RORC, IL13RA2, IL6, IL9, IL15, IL2RA, TRA@, SOCS3, STAT1, STAT5A |
| Growth of eukaryotic cells | .0000 | CDKN1A, STAT1, STAT5A, TGFBR3, HGF, CRH, CCND2, PTP4A3, PTPRG, NTRK3, ADCY1, ATF3, ATF5, CD44, COL1A1, COL6A3, CXCL10, CYP19A1, DUSP5, FOXC1, GNA15, GZMB, HOXC6, ID2, IER3, IL6, IL9, IL15, IL13RA2, IL1R1, IL2RA, JUN, JUNB, LMNA, MUC1, PCGF2, PRAME, RASSF4, RRAD, SOCS2, SOCS3, TNFRSF8, TXN, WT1 |
| Proliferation of connective tissue cells | .0007 | HGF, CCND2, CD44, CDKN1A, IL6, IL15, PDGFRA, SOCS3 |
| Proliferation of lymphocytes | .0001 | ADRB2, IL2RA, STAT1, STAT5A, CD44, CD274, CDKN1A, TRA@, TRD@, EBI3, IL6, IL15, SERPINA1, THY1 |
| Signaling of cells | .0000 | IL6, IL15, IL26, IL2RA, CCL5, CCL8, CCL17, CCL22, CD97, CXCL10, GJB2, LILRB2, TNFAIP6, TNFRSF11A, TXN |
| Transcription of gene | .0008 | JUN, NFIB, WT1, FOXC1, STAT1, STAT5A, NFKBIA, HGF, AMPH, ASCL1, ATF3, CD44, DUSP4, EHF, IL6, SOCS3 |
| Canonical pathways | ||
| NF-κB signaling | .0005 | TNFRSF11A, PDGFRA, NFKBIA, TNFAIP3, IL1R2, CARD10, TRA@, IL1R1, TRD@, TLR8 |
| JAK/Stat signaling | .0204 | SOCS3, STAT1, STAT5A, CDKN1A, SOCS2 |
| IL-6 signaling | .0010 | IL6, IL1R1, IL1R2, NFKBIA, CYP19A1, JUN, COL1A1, TNFAIP6 |
| IL-9 signaling | .0017 | IL9, SOCS3, STAT1, STAT5A, SOCS2 |
| Cytotoxic T lymphocyte-mediated apoptosis of target cells | .0339 | GZMB, TRA@, TRD@ |
| Hepatic fibrosis/hepatic stellate cell activation | .0005 | HGF, COL1A1, COL3A1, STAT1, IL1R1, CCL5, PDGFRA, CCR7, IL6, IL1R2 |
| IL-15 production | .0437 | IL15, IL6, STAT1 |