Reduced intensity conditioning and post transplant relapse in 263 patients with detailed report
| . | n . | % . |
|---|---|---|
| Reason for reduced intensity conditioning | ||
| Age of the recipient | 128 | 49.4 |
| Protocol driven | 77 | 29.7 |
| Comorbidity | 46 | 17.5 |
| Intensive pretreatment | 4 | 1.5 |
| Physician decision | 1 | 0.4 |
| Missing | 7 | 2.3 |
| Conditioning regimen | ||
| TBI ± chemotherapy* | 85 | 32.3 |
| Fludarabin + busulfan | 114 | 43.3 |
| Fludarabin + melphalan | 41 | 15.6 |
| Cyclophosphamide + fludarabin ± other chemo | 21 | 8.0 |
| Fludarabin + AraC | 2 | 0.8 |
| Acute GVHD after transplantation | ||
| No | 191 | 72.6 |
| Grade I | 31 | 11.8 |
| ≥ grade II | 39 | 14.8 |
| Missing | 2 | 0.8 |
| Chronic GVHD after transplantation | ||
| No | 172 | 65 |
| Limited | 50 | 19 |
| Extensive | 37 | 14 |
| Missing | 4 | 2 |
| Interval from RIC HSCT to relapse, median (range) | 5.02 (1-60) | |
| % blast in BM at relapse, median, (range; n = 208) | 27 (0-100) | |
| % blast in PB at relapse, median (range; n = 221) | 5 (0-100) | |
| Extramedullary relapse | ||
| Yes | 34 | 12.9 |
| No | 224 | 85.2 |
| Missing | 5 | 1.9 |
| . | n . | % . |
|---|---|---|
| Reason for reduced intensity conditioning | ||
| Age of the recipient | 128 | 49.4 |
| Protocol driven | 77 | 29.7 |
| Comorbidity | 46 | 17.5 |
| Intensive pretreatment | 4 | 1.5 |
| Physician decision | 1 | 0.4 |
| Missing | 7 | 2.3 |
| Conditioning regimen | ||
| TBI ± chemotherapy* | 85 | 32.3 |
| Fludarabin + busulfan | 114 | 43.3 |
| Fludarabin + melphalan | 41 | 15.6 |
| Cyclophosphamide + fludarabin ± other chemo | 21 | 8.0 |
| Fludarabin + AraC | 2 | 0.8 |
| Acute GVHD after transplantation | ||
| No | 191 | 72.6 |
| Grade I | 31 | 11.8 |
| ≥ grade II | 39 | 14.8 |
| Missing | 2 | 0.8 |
| Chronic GVHD after transplantation | ||
| No | 172 | 65 |
| Limited | 50 | 19 |
| Extensive | 37 | 14 |
| Missing | 4 | 2 |
| Interval from RIC HSCT to relapse, median (range) | 5.02 (1-60) | |
| % blast in BM at relapse, median, (range; n = 208) | 27 (0-100) | |
| % blast in PB at relapse, median (range; n = 221) | 5 (0-100) | |
| Extramedullary relapse | ||
| Yes | 34 | 12.9 |
| No | 224 | 85.2 |
| Missing | 5 | 1.9 |
BM indicates bone marrow; TBI, total body irradiation; GVHD, graft-versus-host disease; PB, peripheral blood; Gy, gray; RIC, reduced intensity conditioning; HSCT, hematopoietic stem cell transplantation; and GVHD, graft-versus-host disease.
A total of 2 Gy, n = 79; and 4 Gy, n = 6.