Treatment response and survival according to LEF1 expression in the primary cohort
| . | All patients, n = 210 . | Patients younger than 60 y, n = 109 . | Patients 60 y and older, n = 101 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| LEF1high . | LEF1low . | P . | LEF1high . | LEF1low . | P . | LEF1high . | LEF1low . | P . | |
| CR rate, % | 70 | 57 | .09 | 70 | 68 | > .99 | 69 | 46 | .03 |
| RFS | < .001 | .01 | .004 | ||||||
| Median RFS, mo | 26.8 | 6.7 | nr | 9.8 | 13.5 | 5.7 | |||
| Estimated RFS at 3 y, % (95% CI) | 46 (36-59) | 22 (14-36) | 61 (48-79) | 32 (20-52) | 29 (17-49) | 8 (2-31) | |||
| OS | < .001 | .006 | < .001 | ||||||
| Median OS, mo | 36.2 | 8.6 | 75.8 | 10.7 | 22.8 | 7.8 | |||
| Estimated OS at 3 y, % (95% CI) | 51 (42-62) | 20 (14-30) | 60 (48-74) | 27 (17-42) | 42 (30-58) | 14 (7-28) | |||
| EFS | < .001 | .04 | < .001 | ||||||
| Median EFS, mo | 10.5 | 5.5 | 13.7 | 7.7 | 9.9 | 2.4 | |||
| Estimated EFS at 3 y, % (95% CI) | 32 (24-42) | 13 (8-21) | 43 (31-58) | 22 (13-37) | 20 (11-35) | 4 (0-13) | |||
| . | All patients, n = 210 . | Patients younger than 60 y, n = 109 . | Patients 60 y and older, n = 101 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| LEF1high . | LEF1low . | P . | LEF1high . | LEF1low . | P . | LEF1high . | LEF1low . | P . | |
| CR rate, % | 70 | 57 | .09 | 70 | 68 | > .99 | 69 | 46 | .03 |
| RFS | < .001 | .01 | .004 | ||||||
| Median RFS, mo | 26.8 | 6.7 | nr | 9.8 | 13.5 | 5.7 | |||
| Estimated RFS at 3 y, % (95% CI) | 46 (36-59) | 22 (14-36) | 61 (48-79) | 32 (20-52) | 29 (17-49) | 8 (2-31) | |||
| OS | < .001 | .006 | < .001 | ||||||
| Median OS, mo | 36.2 | 8.6 | 75.8 | 10.7 | 22.8 | 7.8 | |||
| Estimated OS at 3 y, % (95% CI) | 51 (42-62) | 20 (14-30) | 60 (48-74) | 27 (17-42) | 42 (30-58) | 14 (7-28) | |||
| EFS | < .001 | .04 | < .001 | ||||||
| Median EFS, mo | 10.5 | 5.5 | 13.7 | 7.7 | 9.9 | 2.4 | |||
| Estimated EFS at 3 y, % (95% CI) | 32 (24-42) | 13 (8-21) | 43 (31-58) | 22 (13-37) | 20 (11-35) | 4 (0-13) | |||
CR indicates complete remission; RFS, relapse-free survival; OS, overall survival; CI, confidence interval; EFS, event-free survival; and nr, not reached.