Gene pathways aberrantly expressed in MDS HSCs
| Category . | P . | Molecules . |
|---|---|---|
| Genes overexpressed in MDS HSCs | ||
| Cell cycle | .0000000 | ARL8A, BUB1, CCNA2, CCNB1, CCNB2, ECT2, HJURP, NCAPD3, NDC80, NEK2, NUSAP1, SGOL1, SKA2, SKA3 |
| Cancer | .0000031 | AHCY, BRAF, BUB1B, CCNA2, CCNB2, CDKN3, DDX39A, DHFR, EBP, GGH, GINS2, GINS3, GMNN, HDAC3, IL8, ILF2, KIAA0101, KPNA2, MAD2L1, MAPK8, MCM10, MCM4, MLF1IP, NEK2, NQO1, NUDT5, ORC1, PCNA, POLE3, PTTG1, RAE1, RPP40, TMEM97, TRAPPC2L, TUBB2C |
| Gastrointestinal disease | .0000031 | AHCY, BRAF, BUB1B, CCNA2, CCNB2, CDKN3, DDX39A, DHFR, EBP, GGH, GINS2, GINS3, GMNN, HDAC3, IL8, ILF2, KIAA0101, KPNA2, MAD2L1, MAPK8, MCM10, MCM4, MLF1IP, NEK2, NQO1, NUDT5, ORC1, PCNA, POLE3, PTTG1, RAE1, RPP40, TMEM97, TRAPPC2L, TUBB2C |
| Genetic disorder | .0000031 | AHCY, BRAF, BUB1B, CCNA2, CCNB2, CDKN3, DDX39A, DHFR, EBP, GGH, GINS2, GINS3, GMNN, HDAC3, IL8, ILF2, KIAA0101, KPNA2, MAD2L1, MAPK8, MCM10, MCM4, MLF1IP, NEK2, NQO1, NUDT5, ORC1, PCNA, POLE3, PTTG1, RAE1, RPP40, TMEM97, TRAPPC2L, TUBB2C |
| DNA replication, recombination, and repair | .0000330 | BUB1, BUB1B, CCNB1, CHEK2, FANCD2, MAD2L1, MCM7, NDC80, ZWILCH |
| Genes underexpressed in MDS HSCs | ||
| Inflammatory response | .000072 | CCL4, HLA-DRB3 (includes others), HLA-DRB4, IGHE, KLRC4-KLRK1 |
| Cell-to-cell signaling and interaction | .000305 | CCL4, IGHE, KLRC4-KLRK1 |
| Cell death | .00032 | CCL4, HLA-DRB4, IGHE |
| Genetic disorder | .000448 | HLA-DRB3 (includes others), HLA-DRB4 |
| Category . | P . | Molecules . |
|---|---|---|
| Genes overexpressed in MDS HSCs | ||
| Cell cycle | .0000000 | ARL8A, BUB1, CCNA2, CCNB1, CCNB2, ECT2, HJURP, NCAPD3, NDC80, NEK2, NUSAP1, SGOL1, SKA2, SKA3 |
| Cancer | .0000031 | AHCY, BRAF, BUB1B, CCNA2, CCNB2, CDKN3, DDX39A, DHFR, EBP, GGH, GINS2, GINS3, GMNN, HDAC3, IL8, ILF2, KIAA0101, KPNA2, MAD2L1, MAPK8, MCM10, MCM4, MLF1IP, NEK2, NQO1, NUDT5, ORC1, PCNA, POLE3, PTTG1, RAE1, RPP40, TMEM97, TRAPPC2L, TUBB2C |
| Gastrointestinal disease | .0000031 | AHCY, BRAF, BUB1B, CCNA2, CCNB2, CDKN3, DDX39A, DHFR, EBP, GGH, GINS2, GINS3, GMNN, HDAC3, IL8, ILF2, KIAA0101, KPNA2, MAD2L1, MAPK8, MCM10, MCM4, MLF1IP, NEK2, NQO1, NUDT5, ORC1, PCNA, POLE3, PTTG1, RAE1, RPP40, TMEM97, TRAPPC2L, TUBB2C |
| Genetic disorder | .0000031 | AHCY, BRAF, BUB1B, CCNA2, CCNB2, CDKN3, DDX39A, DHFR, EBP, GGH, GINS2, GINS3, GMNN, HDAC3, IL8, ILF2, KIAA0101, KPNA2, MAD2L1, MAPK8, MCM10, MCM4, MLF1IP, NEK2, NQO1, NUDT5, ORC1, PCNA, POLE3, PTTG1, RAE1, RPP40, TMEM97, TRAPPC2L, TUBB2C |
| DNA replication, recombination, and repair | .0000330 | BUB1, BUB1B, CCNB1, CHEK2, FANCD2, MAD2L1, MCM7, NDC80, ZWILCH |
| Genes underexpressed in MDS HSCs | ||
| Inflammatory response | .000072 | CCL4, HLA-DRB3 (includes others), HLA-DRB4, IGHE, KLRC4-KLRK1 |
| Cell-to-cell signaling and interaction | .000305 | CCL4, IGHE, KLRC4-KLRK1 |
| Cell death | .00032 | CCL4, HLA-DRB4, IGHE |
| Genetic disorder | .000448 | HLA-DRB3 (includes others), HLA-DRB4 |