Gene pathways aberrantly methylated in MDS HSCs
| . | Biologic functions . | Genes . |
|---|---|---|
| Hypomethylated in MDS HSCs | ||
| 1 | Gene expression, cellular movement, embryonic development | AKT1S1, CDC16, CDC25B, CDK3, CHAF1B, DTX1, EIF4EBP1, ERBB3, FGFR1, FZR1, GALNT14, GATA4, GRLF1, GRWD1, ITM2C, MUC4, MUC5AC, NOTCH1, PARD3, RPS6KA4, TBX5, TFDP1, TFF1, TP53BP2, TRIM24, WDR5 |
| 2 | Carbohydrate metabolism, lipid metabolism, small-molecule biochemistry | AGRN, CAPN5, CASD1, COL6A2, DDX1, ENG, HIP1, HIP1R, LAMA1, LCAT, LIMS1, MAGEA1 (includes EG:4100), MGAT3, MIA, NANOG, NF2, P4HA3, PDLIM2, PXN, RPL22, SGSM3, SH3GLB2, SLC12A6, TGM2, TSPYL2 |
| 3 | Dermatologic diseases and conditions, genetic disorder, skeletal and muscular system Development and function | CSDC2, CTBP1, EDARADD, HDAC4, KCNC1, KHDRBS2, LTB, MAP3K14, MEOX1, MYOG, NLRC4, OTUB2, PGLYRP1, PKP1, SMYD2, SNRPD3, SRL, STAT5A, SYNCRIP, TARDBP, TNFRSF4, TNPO2, WIZ |
| 4 | Cardiovascular system Development and function, embryonic development, organismal development | CBLC, CYP17A1, CYTH2, DRD5, FZD5, GNG3, GPR35, GPR162, GPR179, IL25, LPAR1, LTB4R2, Mapk, MTNR1A, NCKAP1, NRP1, PLXNA1, PTGDR, PTGER3, RNASE2, SLC12A2, SLC18A3, SLC7A1, SLC9A1 |
| 5 | Cellular movement, respiratory disease, hematologic system development and Function | ANGPT2, CXADR, DNAH1, DUSP1, EPPK1, F7, GNAZ, IFITM1, LTA, MAP3K1, MBP, MFGE8, MICAL2, PIGR, PLA2G7, PON2, PRKCH, PTMA, SLC6A4, TACSTD2, TICAM1 |
| Hypermethylated in MDS HSCs | ||
| 1 | Cancer, reproductive system disease, cardiovascular disease | BAT2, CDK16, CITED1, CLASP1, ECEL1, EREG, GANAB, GOT1, GPAA1, KIDINS220, MAN2C1, MAPRE3, MARK4, MCAM, NMB, P4HA2, PFDN6, PHKA2, PIGK, PPAP2B, SIAH2, SPG20, SPRY2, SRD5A2, TP53I11, TRIP10, TUBA1A, TUBA1C, TUBB, TYROBP |
| 2 | Lipid metabolism, small-molecule biochemistry, gastrointestinal disease | B4GALNT1, CHRNE, CILP, CILP2, DLL3, DOK6, EWSR1, GLS, GP1BB, GSPT1, HIVEP1, LAD1, MEOX2, MSX2, MUC1, NDUFB1, NOTCH4, OLFM2, PGLS, PTCD3, RET, SIX3, ST13, STAG2, SYTL1, TNF, ZDHHC3 |
| 3 | Molecular transport, protein trafficking, behavior | ARL4A, CAMK2A, CCDC106, CDKN1B, CRX, DKK1, DLK1, EFEMP1, HOXA7, KAT2A, MBD1, MLL, MYO1C, NELF, NUTF2, PRKD2, PTCD2, RAN, RFC1, RPL12 (includes EG:6136), RPS5, SETDB1, SETMAR, TBL1X, TNPO2, UHRF1, WDR46 |
| 4 | Gene expression, tissue morphology, nervous system development and function | ALDH1B1, APOE, CBR3, CHSY1, FAM129B, FUCA1, GDPD5, GNAI2, HLTF, IGFBP6, LRRC8A, MTMR6, PHOX2A, PPM1B, PRDX1, RDH10, SP1, SP2, STAT6, STOM, UBE2Z, USP3, USP4, USP48, ZCCHC24 |
| 5 | Cell cycle, cellular growth and proliferation, genetic disorder | ADC, ADRM1, CDKN1A, E4F1, EIF6, EIF3J, EIF4B, HIST1H2AE (includes EG:3012), KIF20A, LYN, NMT1, NR2E1 (includes EG:7101), NUDT5, PHC1, PSMA8, PSMB3, PSMB4, PSMC5, SNCAIP, TGFB1I1, TMEM126B, TNNT1, TRIM41, UBE2I |
| . | Biologic functions . | Genes . |
|---|---|---|
| Hypomethylated in MDS HSCs | ||
| 1 | Gene expression, cellular movement, embryonic development | AKT1S1, CDC16, CDC25B, CDK3, CHAF1B, DTX1, EIF4EBP1, ERBB3, FGFR1, FZR1, GALNT14, GATA4, GRLF1, GRWD1, ITM2C, MUC4, MUC5AC, NOTCH1, PARD3, RPS6KA4, TBX5, TFDP1, TFF1, TP53BP2, TRIM24, WDR5 |
| 2 | Carbohydrate metabolism, lipid metabolism, small-molecule biochemistry | AGRN, CAPN5, CASD1, COL6A2, DDX1, ENG, HIP1, HIP1R, LAMA1, LCAT, LIMS1, MAGEA1 (includes EG:4100), MGAT3, MIA, NANOG, NF2, P4HA3, PDLIM2, PXN, RPL22, SGSM3, SH3GLB2, SLC12A6, TGM2, TSPYL2 |
| 3 | Dermatologic diseases and conditions, genetic disorder, skeletal and muscular system Development and function | CSDC2, CTBP1, EDARADD, HDAC4, KCNC1, KHDRBS2, LTB, MAP3K14, MEOX1, MYOG, NLRC4, OTUB2, PGLYRP1, PKP1, SMYD2, SNRPD3, SRL, STAT5A, SYNCRIP, TARDBP, TNFRSF4, TNPO2, WIZ |
| 4 | Cardiovascular system Development and function, embryonic development, organismal development | CBLC, CYP17A1, CYTH2, DRD5, FZD5, GNG3, GPR35, GPR162, GPR179, IL25, LPAR1, LTB4R2, Mapk, MTNR1A, NCKAP1, NRP1, PLXNA1, PTGDR, PTGER3, RNASE2, SLC12A2, SLC18A3, SLC7A1, SLC9A1 |
| 5 | Cellular movement, respiratory disease, hematologic system development and Function | ANGPT2, CXADR, DNAH1, DUSP1, EPPK1, F7, GNAZ, IFITM1, LTA, MAP3K1, MBP, MFGE8, MICAL2, PIGR, PLA2G7, PON2, PRKCH, PTMA, SLC6A4, TACSTD2, TICAM1 |
| Hypermethylated in MDS HSCs | ||
| 1 | Cancer, reproductive system disease, cardiovascular disease | BAT2, CDK16, CITED1, CLASP1, ECEL1, EREG, GANAB, GOT1, GPAA1, KIDINS220, MAN2C1, MAPRE3, MARK4, MCAM, NMB, P4HA2, PFDN6, PHKA2, PIGK, PPAP2B, SIAH2, SPG20, SPRY2, SRD5A2, TP53I11, TRIP10, TUBA1A, TUBA1C, TUBB, TYROBP |
| 2 | Lipid metabolism, small-molecule biochemistry, gastrointestinal disease | B4GALNT1, CHRNE, CILP, CILP2, DLL3, DOK6, EWSR1, GLS, GP1BB, GSPT1, HIVEP1, LAD1, MEOX2, MSX2, MUC1, NDUFB1, NOTCH4, OLFM2, PGLS, PTCD3, RET, SIX3, ST13, STAG2, SYTL1, TNF, ZDHHC3 |
| 3 | Molecular transport, protein trafficking, behavior | ARL4A, CAMK2A, CCDC106, CDKN1B, CRX, DKK1, DLK1, EFEMP1, HOXA7, KAT2A, MBD1, MLL, MYO1C, NELF, NUTF2, PRKD2, PTCD2, RAN, RFC1, RPL12 (includes EG:6136), RPS5, SETDB1, SETMAR, TBL1X, TNPO2, UHRF1, WDR46 |
| 4 | Gene expression, tissue morphology, nervous system development and function | ALDH1B1, APOE, CBR3, CHSY1, FAM129B, FUCA1, GDPD5, GNAI2, HLTF, IGFBP6, LRRC8A, MTMR6, PHOX2A, PPM1B, PRDX1, RDH10, SP1, SP2, STAT6, STOM, UBE2Z, USP3, USP4, USP48, ZCCHC24 |
| 5 | Cell cycle, cellular growth and proliferation, genetic disorder | ADC, ADRM1, CDKN1A, E4F1, EIF6, EIF3J, EIF4B, HIST1H2AE (includes EG:3012), KIF20A, LYN, NMT1, NR2E1 (includes EG:7101), NUDT5, PHC1, PSMA8, PSMB3, PSMB4, PSMC5, SNCAIP, TGFB1I1, TMEM126B, TNNT1, TRIM41, UBE2I |