Risk of IS and MI following combination of 2 risk factors
| Exposure 1 . | Exposure 2 . | Controls, n . | IS . | MI . | ||||
|---|---|---|---|---|---|---|---|---|
| Cases, n . | OR1 (95% CI) . | OR2 (95% CI) . | Cases, n . | OR1 (95% CI) . | OR2 (95% CI) . | |||
| VWF < p90 | ADAMTS13 > p10 | 507 | 107 | 1 (ref) | 1 (ref) | 130 | 1 (ref) | 1 (ref) |
| VWF < p90 | ADAMTS13 ≤ p10 | 57 | 20 | 2.2 (1.2-4.1) | 2.0 (1.1-3.8) | 21 | 1.6 (0.9-2.8) | 1.4 (0.8-2.5) |
| VWF ≥ p90 | ADAMTS13 > p10 | 57 | 31 | 3.2 (1.8-5.5) | 3.1 (1.7-5.5) | 39 | 2.6 (1.6-4.2) | 2.6 (1.6-4.3) |
| VWF ≥ p90 | ADAMTS13 ≤ p10 | 5 | 9 | 6.9 (2.0-23.0) | 5.8 (1.7-20.2) | 12 | 11.3 (3.6-35.2) | 9.8 (3.1-30.9) |
| VWF < p90 | No OC use | 372 | 65 | 1 (ref) | 1 (ref) | 92 | 1 (ref) | 1 (ref) |
| VWF < p90 | OC use | 192 | 62 | 2.2 (1.3-3.5) | 2.0 (1.2-3.3) | 59 | 2.2 (1.5-3.4) | 2.1 (1.4-3.3) |
| VWF ≥ p90 | No OC use | 45 | 14 | 1.8 (0.9-3.8) | 1.6 (0.8-3.5) | 29 | 2.7 (1.5-4.7) | 2.8 (1.5-5.0) |
| VWF ≥ p90 | OC use | 17 | 26 | 12.0 (5.5-26.2) | 11.4 (5.2-25.3) | 22 | 7.5 (3.6-15.7) | 7.1 (3.3-15.3) |
| ADAMTS13 > p10 | No OC use | 384 | 69 | 1 (ref) | 1 (ref) | 103 | 1 (ref) | 1 (ref) |
| ADAMTS13 > p10 | OC use | 180 | 69 | 2.6 (1.7-4.3) | 2.6 (1.6-4.1) | 66 | 2.6 (1.7-3.9) | 2.5 (1.6-3.8) |
| ADAMTS13 ≤ p10 | No OC use | 33 | 10 | 2.0 (0.9-4.6) | 1.8 (0.8-4.3) | 18 | 2.5 (1.3-4.9) | 2.3 (1.1-4.5) |
| ADAMTS13 ≤ p10 | OC use | 29 | 19 | 5.8 (2.7-12.4) | 5.1 (2.4-11.2) | 15 | 3.0 (1.4-6.2) | 2.7 (1.3-5.7) |
| Exposure 1 . | Exposure 2 . | Controls, n . | IS . | MI . | ||||
|---|---|---|---|---|---|---|---|---|
| Cases, n . | OR1 (95% CI) . | OR2 (95% CI) . | Cases, n . | OR1 (95% CI) . | OR2 (95% CI) . | |||
| VWF < p90 | ADAMTS13 > p10 | 507 | 107 | 1 (ref) | 1 (ref) | 130 | 1 (ref) | 1 (ref) |
| VWF < p90 | ADAMTS13 ≤ p10 | 57 | 20 | 2.2 (1.2-4.1) | 2.0 (1.1-3.8) | 21 | 1.6 (0.9-2.8) | 1.4 (0.8-2.5) |
| VWF ≥ p90 | ADAMTS13 > p10 | 57 | 31 | 3.2 (1.8-5.5) | 3.1 (1.7-5.5) | 39 | 2.6 (1.6-4.2) | 2.6 (1.6-4.3) |
| VWF ≥ p90 | ADAMTS13 ≤ p10 | 5 | 9 | 6.9 (2.0-23.0) | 5.8 (1.7-20.2) | 12 | 11.3 (3.6-35.2) | 9.8 (3.1-30.9) |
| VWF < p90 | No OC use | 372 | 65 | 1 (ref) | 1 (ref) | 92 | 1 (ref) | 1 (ref) |
| VWF < p90 | OC use | 192 | 62 | 2.2 (1.3-3.5) | 2.0 (1.2-3.3) | 59 | 2.2 (1.5-3.4) | 2.1 (1.4-3.3) |
| VWF ≥ p90 | No OC use | 45 | 14 | 1.8 (0.9-3.8) | 1.6 (0.8-3.5) | 29 | 2.7 (1.5-4.7) | 2.8 (1.5-5.0) |
| VWF ≥ p90 | OC use | 17 | 26 | 12.0 (5.5-26.2) | 11.4 (5.2-25.3) | 22 | 7.5 (3.6-15.7) | 7.1 (3.3-15.3) |
| ADAMTS13 > p10 | No OC use | 384 | 69 | 1 (ref) | 1 (ref) | 103 | 1 (ref) | 1 (ref) |
| ADAMTS13 > p10 | OC use | 180 | 69 | 2.6 (1.7-4.3) | 2.6 (1.6-4.1) | 66 | 2.6 (1.7-3.9) | 2.5 (1.6-3.8) |
| ADAMTS13 ≤ p10 | No OC use | 33 | 10 | 2.0 (0.9-4.6) | 1.8 (0.8-4.3) | 18 | 2.5 (1.3-4.9) | 2.3 (1.1-4.5) |
| ADAMTS13 ≤ p10 | OC use | 29 | 19 | 5.8 (2.7-12.4) | 5.1 (2.4-11.2) | 15 | 3.0 (1.4-6.2) | 2.7 (1.3-5.7) |
ORs were calculated by logistic regression and were adjusted for age, year of event/index year, and area of residence. OR2 values were also adjusted for hypercholesterolemia, hypertension, diabetes mellitus, and smoking.
ref indicates reference.