Table 2

Pharmacokinetic parameters after oral DAC versus oral THU-DAC in female mice (mean values from 3 mice at each time point in each group)

GroupTHU-DAC 0.1THU-DAC 0.2THU-DAC 0.4DAC 0.4 only
DAC dose, mg/kg 0.1 0.2 0.4 0.4 
THU dose, mg/kg 167 167 167 0 
AUCt, min/μM 17.90 35.64 76.24 8.45 
Cmax, μM 0.138 0.338 0.617 0.251 
AUCt coefficient of variation   0.15 0.24 
GroupTHU-DAC 0.1THU-DAC 0.2THU-DAC 0.4DAC 0.4 only
DAC dose, mg/kg 0.1 0.2 0.4 0.4 
THU dose, mg/kg 167 167 167 0 
AUCt, min/μM 17.90 35.64 76.24 8.45 
Cmax, μM 0.138 0.338 0.617 0.251 
AUCt coefficient of variation   0.15 0.24 
*

Drugs were administered 2 times per week for 3 weeks and blood for pharmacokinetic analysis was collected on the last day of dosing (day 16).

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