Univariate transfusion factors (P > .05)
| Transfusion risk factor assessed for each patient . | OR . | Lower 95% CI . | Upper 95% CI . | P . |
|---|---|---|---|---|
| Blood or blood component received | ||||
| RBCs from female donor | 0.62 | 0.35 | 1.08 | .09 |
| RBCs from previously pregnant female donor | 0.79 | 0.45 | 1.38 | .40 |
| Cytokines: sum of amounts (concentration × volume) in all units received | ||||
| IL-6 | 1.14 | 0.997 | 1.30 | .06 |
| IL-8 | 1.26 | 0.96 | 1.63 | .09 |
| GM-CSF | 1.00 | 0.999 | 1.00 | .52 |
| IFN-γ | 1.24 | 0.99 | 1.56 | .06 |
| TNF-α | 1.10 | 0.96 | 1.27 | .18 |
| Soluble CD40 ligand (sCD40L) | 1.06 | 0.97 | 1.16 | .22 |
| Platelet factor 4 (PF4) | 1.06 | 0.98 | 1.14 | .14 |
| Neutrophil priming activity: sum of amounts (activity × volume) in all units received | ||||
| CD11b/CD66b up-regulation | 1.00 | 0.95 | 1.04 | .82 |
| No. of leuko-reduced RBC units received by each patient, by RBC unit storage age | ||||
| RBC units vs other units | 1.02 | 0.90 | 1.15 | .77 |
| No. of RBC units > 7-day-old vs other RBC units | 1.02 | 0.76 | 1.37 | .88 |
| No. of RBC units > 14 days vs other RBC units | 1.03 | 0.87 | 1.23 | .72 |
| No. of RBC units > 21-day-old vs other RBC units | 1.13 | 0.95 | 1.34 | .16 |
| No. of RBC units > 28-day-old vs other RBC units | 1.03 | 0.81 | 1.31 | .79 |
| No. of RBC units > 35-day-old vs other RBC units | 0.99 | 0.76 | 1.29 | .95 |
| Median age of all RBCs vs other RBC units | 1.01 | 0.99 | 1.03 | .49 |
| Mean age of all RBC units | 1.01 | 0.99 | 1.03 | .41 |
| Maximum age among all RBC units | 1.01 | 0.99 | 1.03 | .26 |
| Apheresis platelet unit storage age | ||||
| Platelets > 3-day-old vs other platelets | 0.67 | 0.27 | 1.68 | .39 |
| Platelets > 4-day-old vs other | 1.24 | 0.72 | 2.1 | .45 |
| Platelet median unit age | 1.07 | 0.96 | 1.20 | .20 |
| Platelet mean unit age | 1.07 | 0.96 | 1.2 | .22 |
| Platelet maximum unit age | 1.07 | 0.96 | 1.2 | .20 |
| Transfusion risk factor assessed for each patient . | OR . | Lower 95% CI . | Upper 95% CI . | P . |
|---|---|---|---|---|
| Blood or blood component received | ||||
| RBCs from female donor | 0.62 | 0.35 | 1.08 | .09 |
| RBCs from previously pregnant female donor | 0.79 | 0.45 | 1.38 | .40 |
| Cytokines: sum of amounts (concentration × volume) in all units received | ||||
| IL-6 | 1.14 | 0.997 | 1.30 | .06 |
| IL-8 | 1.26 | 0.96 | 1.63 | .09 |
| GM-CSF | 1.00 | 0.999 | 1.00 | .52 |
| IFN-γ | 1.24 | 0.99 | 1.56 | .06 |
| TNF-α | 1.10 | 0.96 | 1.27 | .18 |
| Soluble CD40 ligand (sCD40L) | 1.06 | 0.97 | 1.16 | .22 |
| Platelet factor 4 (PF4) | 1.06 | 0.98 | 1.14 | .14 |
| Neutrophil priming activity: sum of amounts (activity × volume) in all units received | ||||
| CD11b/CD66b up-regulation | 1.00 | 0.95 | 1.04 | .82 |
| No. of leuko-reduced RBC units received by each patient, by RBC unit storage age | ||||
| RBC units vs other units | 1.02 | 0.90 | 1.15 | .77 |
| No. of RBC units > 7-day-old vs other RBC units | 1.02 | 0.76 | 1.37 | .88 |
| No. of RBC units > 14 days vs other RBC units | 1.03 | 0.87 | 1.23 | .72 |
| No. of RBC units > 21-day-old vs other RBC units | 1.13 | 0.95 | 1.34 | .16 |
| No. of RBC units > 28-day-old vs other RBC units | 1.03 | 0.81 | 1.31 | .79 |
| No. of RBC units > 35-day-old vs other RBC units | 0.99 | 0.76 | 1.29 | .95 |
| Median age of all RBCs vs other RBC units | 1.01 | 0.99 | 1.03 | .49 |
| Mean age of all RBC units | 1.01 | 0.99 | 1.03 | .41 |
| Maximum age among all RBC units | 1.01 | 0.99 | 1.03 | .26 |
| Apheresis platelet unit storage age | ||||
| Platelets > 3-day-old vs other platelets | 0.67 | 0.27 | 1.68 | .39 |
| Platelets > 4-day-old vs other | 1.24 | 0.72 | 2.1 | .45 |
| Platelet median unit age | 1.07 | 0.96 | 1.20 | .20 |
| Platelet mean unit age | 1.07 | 0.96 | 1.2 | .22 |
| Platelet maximum unit age | 1.07 | 0.96 | 1.2 | .20 |
The transfusion univariate risk factors in this table were not statistically significant. Numbers of patients who received or did not receive this transfusion risk factor are not available because multiple imputation was used for units with missing data (“Statistical methods: risk factor analysis”).