Offspring resulting from Cre-transgenic matings
| Cre . | Total number of mice . | Number of Sykfl/flCre+ or Clec1bfl/flCre+ . | |
|---|---|---|---|
| Expected . | Found . | ||
| Syk | |||
| LysM | 139 | 34.8 | 51 |
| hCD2 | 93 | 18.9 | 18 |
| Vav | 207 | 54.5 | 35* |
| Tie1 | 155 | 37.4 | 28 |
| CD11c | 62 | 37.8 | 36 |
| PF4 | 108 | 32.5 | 17† |
| Tie1+Vav | 50 | 12.5 | 4 |
| Clec1b | |||
| PF4 | 81 | 29.8 | 26 |
| Cre . | Total number of mice . | Number of Sykfl/flCre+ or Clec1bfl/flCre+ . | |
|---|---|---|---|
| Expected . | Found . | ||
| Syk | |||
| LysM | 139 | 34.8 | 51 |
| hCD2 | 93 | 18.9 | 18 |
| Vav | 207 | 54.5 | 35* |
| Tie1 | 155 | 37.4 | 28 |
| CD11c | 62 | 37.8 | 36 |
| PF4 | 108 | 32.5 | 17† |
| Tie1+Vav | 50 | 12.5 | 4 |
| Clec1b | |||
| PF4 | 81 | 29.8 | 26 |
Lineage-specific deletion of Syk and Clec1b with the use of the Cre-recombinase lines indicated. The number of mice with homozygous deletion of Syk or Clec1b expected versus the actual number genotyped is shown.
Significant reduction in the number of mice as indicated by the χ2 test (P < .05).
Significant reduction in the number of mice as indicated by the χ2 test (P < .005).