Clinicopathologic features of “pediatric-type” (BCL2-N/HPI) follicular lymphomas
| . | Age < 18 years (n = 12) . | Age ≥ 18 years (n = 22) . | P . |
|---|---|---|---|
| Clinical features | |||
| M:F | 12:0 | 14:8 | .03 |
| Head and neck site | 10/12 (83) | 15/22 (68) | .44 |
| Stage I | 12/12 (100) | 22/22 (100) | 1.0 |
| Histologic features | |||
| Marginal zone differentiation | 2/12 (17) | 2/22 (9) | .60 |
| Follicle size > 2 mm diameter | 9/12 (75) | 10/21 (48) | .15 |
| > 50% “Starry-sky” follicles | 9/12 (75) | 11/22 (50) | .27 |
| Histologic grade 3 | 6/12 (50) | 11/22* (50) | 1.0 |
| Immunophenotypic features | |||
| BCL2+ tumor cells ( ≥ 2+ intensity) | 3/12 (25) | 3/22 (14) | .64 |
| Ki67 PI (median) | 90% (40-95%) | 65% (40-95%) | .06 |
| Treatment† | |||
| Excision only | 9/12 (75) | 5/18 (28) | ND |
| Radiation therapy only | 0/12 (0) | 3/18 (17) | |
| Chemotherapy (at initial diagnosis or after radiation therapy) | 3/12 (25) | 10/18 (56) | |
| Median follow-up, mo | 53 | 60 | .84 |
| . | Age < 18 years (n = 12) . | Age ≥ 18 years (n = 22) . | P . |
|---|---|---|---|
| Clinical features | |||
| M:F | 12:0 | 14:8 | .03 |
| Head and neck site | 10/12 (83) | 15/22 (68) | .44 |
| Stage I | 12/12 (100) | 22/22 (100) | 1.0 |
| Histologic features | |||
| Marginal zone differentiation | 2/12 (17) | 2/22 (9) | .60 |
| Follicle size > 2 mm diameter | 9/12 (75) | 10/21 (48) | .15 |
| > 50% “Starry-sky” follicles | 9/12 (75) | 11/22 (50) | .27 |
| Histologic grade 3 | 6/12 (50) | 11/22* (50) | 1.0 |
| Immunophenotypic features | |||
| BCL2+ tumor cells ( ≥ 2+ intensity) | 3/12 (25) | 3/22 (14) | .64 |
| Ki67 PI (median) | 90% (40-95%) | 65% (40-95%) | .06 |
| Treatment† | |||
| Excision only | 9/12 (75) | 5/18 (28) | ND |
| Radiation therapy only | 0/12 (0) | 3/18 (17) | |
| Chemotherapy (at initial diagnosis or after radiation therapy) | 3/12 (25) | 10/18 (56) | |
| Median follow-up, mo | 53 | 60 | .84 |