Clinicopathologic features of adults with stage I follicular lymphomas (cohort 2)
| . | BCL2-N/HPI (n = 13) . | Other stage I (n = 15) . | P . |
|---|---|---|---|
| Clinical features | |||
| Age, y (median) | 37 (18-61) | 62 (39-82) | .0005 |
| M:F | 8:5 | 7:8 | .47 |
| Head and neck site | 8/13 (62) | 6/15 (40) | .27 |
| Histologic features | |||
| Diffuse areas | 1/13 (8) | 7/15 (47) | .04 |
| Marginal zone differentiation | 1/13 (8) | 0/15 (0) | .46 |
| Follicle size > 2 mm diameter | 5/12 (42) | 3/15 (20) | .40 |
| > 50% “Starry-sky” follicles | 7/12 (58) | 0/15 (0) | .001 |
| Histologic grade 3* | 8/13 (62) | 1/15 (7) | .004 |
| Treatment† | |||
| Excision only | 0/9 (0) | 1/15 (7) | ND |
| Radiation therapy only | 2/9 (22) | 7/15 (47)‡ | |
| Chemotherapy (at initial diagnosis or after radiation therapy) | 7/9 (78) | 7/15 (47) | |
| Outcome | |||
| Relapse or progression | 0/13 (0) | 11/15 (73) | < .0001 |
| Persistent disease at latest follow-up | 0/13 (0) | 6/15 (40) | .02 |
| Died from disease | 0/13 (0) | 1/15 (7) | 1.0 |
| . | BCL2-N/HPI (n = 13) . | Other stage I (n = 15) . | P . |
|---|---|---|---|
| Clinical features | |||
| Age, y (median) | 37 (18-61) | 62 (39-82) | .0005 |
| M:F | 8:5 | 7:8 | .47 |
| Head and neck site | 8/13 (62) | 6/15 (40) | .27 |
| Histologic features | |||
| Diffuse areas | 1/13 (8) | 7/15 (47) | .04 |
| Marginal zone differentiation | 1/13 (8) | 0/15 (0) | .46 |
| Follicle size > 2 mm diameter | 5/12 (42) | 3/15 (20) | .40 |
| > 50% “Starry-sky” follicles | 7/12 (58) | 0/15 (0) | .001 |
| Histologic grade 3* | 8/13 (62) | 1/15 (7) | .004 |
| Treatment† | |||
| Excision only | 0/9 (0) | 1/15 (7) | ND |
| Radiation therapy only | 2/9 (22) | 7/15 (47)‡ | |
| Chemotherapy (at initial diagnosis or after radiation therapy) | 7/9 (78) | 7/15 (47) | |
| Outcome | |||
| Relapse or progression | 0/13 (0) | 11/15 (73) | < .0001 |
| Persistent disease at latest follow-up | 0/13 (0) | 6/15 (40) | .02 |
| Died from disease | 0/13 (0) | 1/15 (7) | 1.0 |