Overview of the stimuli that regulate Cdh1 gene expression in epithelial cells, cells of the macrophage lineage, and DCs
| Triggers . | Transcription activators/repressors . | Reference(s) . |
|---|---|---|
| Epithelial cells | ||
| Cdh1 induction | ||
| ND | AP2, Rb, c-Myc, WT1, HNF3/AML-1/p300 | 2 |
| Cdh1 repression | ||
| TGF-β, NF-κB, FGF, HGF, EGF, integrin engagement, hypoxia | Snail, Slug, E12/E47, deltaEF1/ZEB1, SIP1/ZEB2, Twist, HOXB7, CBF-A, KLF8 | 2 |
| LCs | ||
| Cdh1 induction | ||
| TGF-β | ND (SMAD?) | 69 |
| Cdh1 repression | ||
| TLR ligands, TNF, IL-1β | ND (NF-κB?) | 70, 71 |
| DCs | ||
| No data available on Cdh1 regulation in DCs | ||
| Macrophages | ||
| Cdh1 induction | ||
| IL-4/IL-13 alone or in synergy with IL-10 and TGF-β; TREM-2/DAP12 signaling needed | STAT-6, polyamines | 88,–90, 94 |
| Cdh1 repression | ||
| IFN-γ, LPS | ND (STAT-1, NF-κB?) | 90 |
| Triggers . | Transcription activators/repressors . | Reference(s) . |
|---|---|---|
| Epithelial cells | ||
| Cdh1 induction | ||
| ND | AP2, Rb, c-Myc, WT1, HNF3/AML-1/p300 | 2 |
| Cdh1 repression | ||
| TGF-β, NF-κB, FGF, HGF, EGF, integrin engagement, hypoxia | Snail, Slug, E12/E47, deltaEF1/ZEB1, SIP1/ZEB2, Twist, HOXB7, CBF-A, KLF8 | 2 |
| LCs | ||
| Cdh1 induction | ||
| TGF-β | ND (SMAD?) | 69 |
| Cdh1 repression | ||
| TLR ligands, TNF, IL-1β | ND (NF-κB?) | 70, 71 |
| DCs | ||
| No data available on Cdh1 regulation in DCs | ||
| Macrophages | ||
| Cdh1 induction | ||
| IL-4/IL-13 alone or in synergy with IL-10 and TGF-β; TREM-2/DAP12 signaling needed | STAT-6, polyamines | 88,–90, 94 |
| Cdh1 repression | ||
| IFN-γ, LPS | ND (STAT-1, NF-κB?) | 90 |
ND indicates not determined.