ODSH has only minimal anticoagulant activity
| . | aPTT, s . | Anti-Xa UFH, IU/mL . | ||
|---|---|---|---|---|
| +Buffer . | +2 μg/mL UFH . | +Buffer . | +2 μg/mL UFH . | |
| +Buffer | 31.7 | 49.0 | 0.00 | 0.10 |
| +1 μg/mL ODSH | 31.1 | 48.0 | 0.04 | 0.11 |
| +2 μg/mL ODSH | 33.1 | 48.4 | 0.02 | 0.11 |
| +4 μg/mL ODSH | 33.0 | 51.5 | 0.02 | 0.11 |
| +8 μg/mL ODSH | 35.8 | 55.8 | 0.02 | 0.13 |
| +16 μg/mL ODSH | 41.6 | 64.7 | 0.04 | 0.14 |
| . | aPTT, s . | Anti-Xa UFH, IU/mL . | ||
|---|---|---|---|---|
| +Buffer . | +2 μg/mL UFH . | +Buffer . | +2 μg/mL UFH . | |
| +Buffer | 31.7 | 49.0 | 0.00 | 0.10 |
| +1 μg/mL ODSH | 31.1 | 48.0 | 0.04 | 0.11 |
| +2 μg/mL ODSH | 33.1 | 48.4 | 0.02 | 0.11 |
| +4 μg/mL ODSH | 33.0 | 51.5 | 0.02 | 0.11 |
| +8 μg/mL ODSH | 35.8 | 55.8 | 0.02 | 0.13 |
| +16 μg/mL ODSH | 41.6 | 64.7 | 0.04 | 0.14 |
ODSH indicates 2-O, 3-O desulfated heparin; aPTT, activated thromboplastin time; and UFH, unfractionated heparin.
aPTT and anti-Xa activity in pooled plasma (n = 25) was analyzed in the presence of buffer (0.9% saline; baseline activity), or 2 μg/mL (∼ 0.3 IU/mL) UFH alone (line 1). Then increasing concentrations of ODSH were added. Up to a concentration of 4 μg/mL, ODSH had only minimal effects on the aPTT or anti-Xa activity.