Table 1

Critical values of CD69 and CD154 suppression by freshly isolated Tregs as a diagnostic test for inhibition of proliferation at 96 hours

Marker and valuesSensitivity, % (95% CI)Specificity, % (95% CI)PPV, %NPV, %LR+LR
CD69       
    Lower quartile: > 9.9% 93 (68-100) 40 (20-64) 61 86 1.6 0.2 
    Median: > 28.6% 67 (42-85) 67 (42-85) 67 67 2.0 0.5 
    Upper quartile: > 39.6% 40 (20-64) 93 (68-100) 86 61 6.0 0.6 
    Minimum cost: 37.4% 53 (30-75) 93 (68-100) 89 67 8.0 0.5 
CD154       
    Lower quartile: > 17.4% 86 (61-97) 40 (20-64) 59 75 1.4 0.3 
    Median: > 37.2% 67 (42-85) 73 (48-89) 71 69 2.5 0.5 
    Upper quartile: > 48.4% 33 (15-59) 93 (68-100) 83 58 5.0 0.7 
    Minimum cost: 43% 53 (30-75) 93 (68-100) 89 67 8.0 0.5 
Marker and valuesSensitivity, % (95% CI)Specificity, % (95% CI)PPV, %NPV, %LR+LR
CD69       
    Lower quartile: > 9.9% 93 (68-100) 40 (20-64) 61 86 1.6 0.2 
    Median: > 28.6% 67 (42-85) 67 (42-85) 67 67 2.0 0.5 
    Upper quartile: > 39.6% 40 (20-64) 93 (68-100) 86 61 6.0 0.6 
    Minimum cost: 37.4% 53 (30-75) 93 (68-100) 89 67 8.0 0.5 
CD154       
    Lower quartile: > 17.4% 86 (61-97) 40 (20-64) 59 75 1.4 0.3 
    Median: > 37.2% 67 (42-85) 73 (48-89) 71 69 2.5 0.5 
    Upper quartile: > 48.4% 33 (15-59) 93 (68-100) 83 58 5.0 0.7 
    Minimum cost: 43% 53 (30-75) 93 (68-100) 89 67 8.0 0.5 

PPV indicates positive predictive value; NPV, negative predictive value; LR+, likelihood ratio of a positive result; and LR, likelihood ratio of a negative result.

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