Adjusted mean of FVIII activity (%) by VWF SNPs
| VWF SNP . | ABO adjusted . | FVIII activity for VWF genotype, mean (SEM) . | P . | ||
|---|---|---|---|---|---|
| AA . | AB . | BB . | |||
| EA women, N = 4282*†§ | |||||
| RS216315 | No | 126.50 (0.54) | 120.66 (1.22) | 117.91 (5.02) | 2.4 × 10−5 |
| Yes | 126.53 (0.51) | 120.53 (1.14) | 117.88 (4.69) | 2.7 × 10−6 | |
| RS216318 | No | 126.51 (0.54) | 120.66 (1.22) | 117.87 (4.90) | 2.2 × 10−5 |
| Yes | 126.54 (0.51) | 120.51 (1.14) | 117.89 (4.58) | 2.3 × 10−6 | |
| RS216299 | No | 126.30 (0.55) | 121.67 (1.20) | 121.81 (4.46) | 1.5 × 10−3 |
| Yes | 126.42 (0.51) | 121.19 (1.12) | 120.51 (4.17) | 6.2 × 10−5 | |
| RS216295 | No | 126.34 (0.55) | 121.70 (1.21) | 119.86 (4.92) | 1.1 × 10−3 |
| Yes | 126.42 (0.51) | 121.36 (1.13) | 118.76 (4.59) | 8 × 10−5 | |
| RS216298 | No | 126.32 (0.54) | 121.61 (1.21) | 119.77 (4.80) | 8.7 × 10−4 |
| Yes | 126.43 (0.51) | 121.15 (1.13) | 118.81 (4.48) | 3.6 × 10−5 | |
| EA men, N = 3774*† | |||||
| RS1063857 | No | 118.24 (0.83) | 122.25 (0.77) | 125.11 (1.45) | 1.9 × 10−5 |
| Yes | 118.50 (0.78) | 122.11 (0.73) | 124.81 (1.38) | 4.3 × 10−5 | |
| RS723190‡§ | No | 120.42 (0.56) | 125.67 (1.57) | 1.6 × 10−3 | |
| Yes | 120.36 (0.53) | 126.13 (1.48) | 2.5 × 10−4 | ||
| VWF SNP . | ABO adjusted . | FVIII activity for VWF genotype, mean (SEM) . | P . | ||
|---|---|---|---|---|---|
| AA . | AB . | BB . | |||
| EA women, N = 4282*†§ | |||||
| RS216315 | No | 126.50 (0.54) | 120.66 (1.22) | 117.91 (5.02) | 2.4 × 10−5 |
| Yes | 126.53 (0.51) | 120.53 (1.14) | 117.88 (4.69) | 2.7 × 10−6 | |
| RS216318 | No | 126.51 (0.54) | 120.66 (1.22) | 117.87 (4.90) | 2.2 × 10−5 |
| Yes | 126.54 (0.51) | 120.51 (1.14) | 117.89 (4.58) | 2.3 × 10−6 | |
| RS216299 | No | 126.30 (0.55) | 121.67 (1.20) | 121.81 (4.46) | 1.5 × 10−3 |
| Yes | 126.42 (0.51) | 121.19 (1.12) | 120.51 (4.17) | 6.2 × 10−5 | |
| RS216295 | No | 126.34 (0.55) | 121.70 (1.21) | 119.86 (4.92) | 1.1 × 10−3 |
| Yes | 126.42 (0.51) | 121.36 (1.13) | 118.76 (4.59) | 8 × 10−5 | |
| RS216298 | No | 126.32 (0.54) | 121.61 (1.21) | 119.77 (4.80) | 8.7 × 10−4 |
| Yes | 126.43 (0.51) | 121.15 (1.13) | 118.81 (4.48) | 3.6 × 10−5 | |
| EA men, N = 3774*† | |||||
| RS1063857 | No | 118.24 (0.83) | 122.25 (0.77) | 125.11 (1.45) | 1.9 × 10−5 |
| Yes | 118.50 (0.78) | 122.11 (0.73) | 124.81 (1.38) | 4.3 × 10−5 | |
| RS723190‡§ | No | 120.42 (0.56) | 125.67 (1.57) | 1.6 × 10−3 | |
| Yes | 120.36 (0.53) | 126.13 (1.48) | 2.5 × 10−4 | ||
SNP indicates single nucleotide polymorphism; and EA, Americans of European descent.
All means were adjusted for age, sex, BMI, diabetes, hypertension, and ever-smoking status.
RS7968035, RS2239143, RS16932374, and RS3213721 were too sparse to analyze for both EA women and men.
Due to small counts, AB genotype was combined with the minor BB genotype.
All SNPs except RS723190 were previously associated with VWF Ag.31