Statistical significance of association of FVIII SNPs with the FVIII-VWF ratio for EA subjects
| SNP . | ABO adjusted . | P (men, N = 3774)* . | P (women, N = 4282)† . |
|---|---|---|---|
| RS4898352 | No | 5.2 × 10−6 | 3.1 × 10−6 |
| Yes | 2.8 × 10−6 | 4.6 × 10−6 | |
| RS5987077 | No | 1.2 × 10−5 | 5.6 × 10−6 |
| Yes | 6.1 × 10−6 | 7.2 × 10−6 | |
| RS1470586 | No | 1.2 × 10−6 | 8.2 × 10−6 |
| Yes | 8.5 × 10−7 | 1.3 × 10−5 | |
| RS6643622 | No | 4.7 × 10−5 | 1.1 × 10−5 |
| Yes | 2.3 × 10−5 | 1.7 × 10−5 | |
| RS5945122‡ | No | 2.1 × 10−4 | 4.9 × 10−4 |
| Yes | 3.8 × 10−4 | 5 × 10−4 | |
| RS5945258‡ | No | 1.7 × 10−4 | 5.6 × 10−4 |
| Yes | 2.9 × 10−4 | 5.7 × 10−4 | |
| RS6643714‡ | No | 2.2 × 10−7 | 8.9 × 10−4 |
| Yes | 1.5 × 10−7 | 1 × 10−4 | |
| RS7061362‡ | No | >2 × 10−4 | 5.1 × 10−4 |
| Yes | 3.7 × 10−4 | 5.1 × 10−4 |
| SNP . | ABO adjusted . | P (men, N = 3774)* . | P (women, N = 4282)† . |
|---|---|---|---|
| RS4898352 | No | 5.2 × 10−6 | 3.1 × 10−6 |
| Yes | 2.8 × 10−6 | 4.6 × 10−6 | |
| RS5987077 | No | 1.2 × 10−5 | 5.6 × 10−6 |
| Yes | 6.1 × 10−6 | 7.2 × 10−6 | |
| RS1470586 | No | 1.2 × 10−6 | 8.2 × 10−6 |
| Yes | 8.5 × 10−7 | 1.3 × 10−5 | |
| RS6643622 | No | 4.7 × 10−5 | 1.1 × 10−5 |
| Yes | 2.3 × 10−5 | 1.7 × 10−5 | |
| RS5945122‡ | No | 2.1 × 10−4 | 4.9 × 10−4 |
| Yes | 3.8 × 10−4 | 5 × 10−4 | |
| RS5945258‡ | No | 1.7 × 10−4 | 5.6 × 10−4 |
| Yes | 2.9 × 10−4 | 5.7 × 10−4 | |
| RS6643714‡ | No | 2.2 × 10−7 | 8.9 × 10−4 |
| Yes | 1.5 × 10−7 | 1 × 10−4 | |
| RS7061362‡ | No | >2 × 10−4 | 5.1 × 10−4 |
| Yes | 3.7 × 10−4 | 5.1 × 10−4 |
Models are adjusted for age, BMI, ever smoking, diabetes, and hypertension (1 subject with outlier was not included from these models).
SNP indicates single nucleotide polymorphism; and EA, Americans of European descent.
There were 37 men were missing information on at least 1 of the predictors and were excluded from these models.
There were 27 women were missing information on at least 1 of the predictors and were excluded from these models.
These SNPs were associated with FVIII activity in EA males as individual and in haplotypes.