Adjusted mean of FVIII activity (%) by FVIII genotype for EA males (N = 3774)
| SNP* . | Location . | ABO adjusted† . | FVIII activity (%) . | P . | |
|---|---|---|---|---|---|
| AA . | BB . | ||||
| RS5945122 | Intron 13 | No | 121.69 (0.57) | 117.35 (1.34) | 2.9 × 10−3 |
| Yes | 121.77 (0.54) | 116.88 (1.27) | 3.9 × 10−4 | ||
| RS6643714‡ | Intron 14 | No | 122.51 (0.66) | 118.50 (0.86) | 2.2 × 10−4 |
| Yes | 122.52 (0.63) | 118.49 (0.81) | 8.8 × 10−5 | ||
| RS7061362‡ | Intron 11 | No | 121.70 (0.57) | 117.29 (1.34) | 2.5 × 10−3 |
| Yes | 121.78 (0.54) | 116.82 (1.27) | 3.2 × 10−4 | ||
| RS5945258‡ | Intron 11 | No | 121.70 (0.57) | 117.24 (1.34) | 2.2 × 10−3 |
| Yes | 121.78 (0.54) | 116.80 (1.26) | 3 × 10−4 | ||
| SNP* . | Location . | ABO adjusted† . | FVIII activity (%) . | P . | |
|---|---|---|---|---|---|
| AA . | BB . | ||||
| RS5945122 | Intron 13 | No | 121.69 (0.57) | 117.35 (1.34) | 2.9 × 10−3 |
| Yes | 121.77 (0.54) | 116.88 (1.27) | 3.9 × 10−4 | ||
| RS6643714‡ | Intron 14 | No | 122.51 (0.66) | 118.50 (0.86) | 2.2 × 10−4 |
| Yes | 122.52 (0.63) | 118.49 (0.81) | 8.8 × 10−5 | ||
| RS7061362‡ | Intron 11 | No | 121.70 (0.57) | 117.29 (1.34) | 2.5 × 10−3 |
| Yes | 121.78 (0.54) | 116.82 (1.27) | 3.2 × 10−4 | ||
| RS5945258‡ | Intron 11 | No | 121.70 (0.57) | 117.24 (1.34) | 2.2 × 10−3 |
| Yes | 121.78 (0.54) | 116.80 (1.26) | 3 × 10−4 | ||
All models adjusted for age, BMI, diabetes, hypertension, and smoking status.
EA indicates Americans of European descent.
RS5986899, RS5987057, RS5987068, RS5987073, RS7056252, RS12014480, RS1800297, RS5987056, RS5987061, RS7357998, and RS12392769 were too sparse to be analyzed for EA men.
Participants with “-G” at RS8176719 and “GT” at RS8176746 were excluded from the ABO genotype definition (N = 1284) and those with no information on RS8176719 or RS8176746 were also excluded (N = 614).
Due to small counts, AB genotype was combined with minor (BB) genotype.