Table 2 Gene expression probe sets... | American Society of Hematology

Table 2

Gene expression probe sets associated with outcome (EFS) in the entire infant ALL cohort

Rank	Probe set	Gene symbol	Elevated in*	SAM analysis		Cox regression analysis		P (adjusted for MLL)†	P (adjusted for age)‡
Rank	Probe set	Gene symbol	Elevated in*	Score	FDR (%)	HR	P§	P (adjusted for MLL)†	P (adjusted for age)‡
1	211382_s_at	*TACC2*	High risk	2.50	< 1	1.51	.001	.007	.001
2	228462_at	*IRX2*	High risk	2.23	< 1	1.45	.001	.006	.002
3	202289_s_at	*TACC2*	High risk	2.15	< 1	1.42	.003	.028	.007
4	205403_at	*IL1R2*	High risk	1.99	< 1	1.48	.001	.018	.016
5	206674_at	*FLT3*	High risk	1.94	< 1	1.54	.009	.248	.002
6	202609_at	EPS8	High risk	1.78	9.77	1.38	.004	.030	.009
7	220448_at	KCNK12	High risk	1.77	9.77	1.39	.019	.428	.015
8	204150_at	STAB1	High risk	1.77	9.77	1.42	.003	.019	.012
9	214156_at	MYRIP	High risk	1.76	9.77	1.49	.001	.008	.008
10	204069_at	MEIS1	High risk	1.72	9.77	1.37	.027	.650	.016

Rank	Probe set	Gene symbol	Elevated in*	SAM analysis		Cox regression analysis		P (adjusted for MLL)†	P (adjusted for age)‡
Rank	Probe set	Gene symbol	Elevated in*	Score	FDR (%)	HR	P§	P (adjusted for MLL)†	P (adjusted for age)‡
1	211382_s_at	*TACC2*	High risk	2.50	< 1	1.51	.001	.007	.001
2	228462_at	*IRX2*	High risk	2.23	< 1	1.45	.001	.006	.002
3	202289_s_at	*TACC2*	High risk	2.15	< 1	1.42	.003	.028	.007
4	205403_at	*IL1R2*	High risk	1.99	< 1	1.48	.001	.018	.016
5	206674_at	*FLT3*	High risk	1.94	< 1	1.54	.009	.248	.002
6	202609_at	EPS8	High risk	1.78	9.77	1.38	.004	.030	.009
7	220448_at	KCNK12	High risk	1.77	9.77	1.39	.019	.428	.015
8	204150_at	STAB1	High risk	1.77	9.77	1.42	.003	.019	.012
9	214156_at	MYRIP	High risk	1.76	9.77	1.49	.001	.008	.008
10	204069_at	MEIS1	High risk	1.72	9.77	1.37	.027	.650	.016

Bold denotes probe sets that are used for building the regression tree model.

Indicates risk group with which elevated expression is correlated.

P value indicating significance of the association between the expression of each gene and treatment outcome adjusting for the MLL status.

P value indicating significance of the association between the expression of each gene and treatment outcome adjusting for age effect.

P value of Wald test for the HR indicating significance of the association between the expression of each individual gene and treatment outcome.