CTL clones tested for Nef-effect
| HLA . | Epitope (location) . | Clone (n)* . | Mean Nef-effect ratio (SD) . | Mean functional avidity (SD)† . |
|---|---|---|---|---|
| A*02 | SLYNTVATL (Gag 77-85) | S1-SL9-1.8 (11) | 0.54 (0.19) | 2.3 (0.6) |
| S1-SL9-1.7 (1) | ||||
| S1-SL9-3.23 (18) | ||||
| S36-SL9-1.9 (10) | ||||
| S36-SL9-10.18 (3) | ||||
| S31-SL9-10.11 (4) | ||||
| TLNAWVKVV (Gag 151-159) | S82-TV9-10.28 (2) | 0.73 (0.09) | 5.0 | |
| AAVDLSHFL (Nef 83-91) | S58-AL9-10.18 (2) | 0.46 | ND | |
| ILKEPVHGV (Pol 446-472) | 68A62-IV9 (8) | 0.46 (0.31) | 4.9 | |
| S31-IV9-10.4 (1) | ||||
| AIIRILQQL (Vpr 59-67) | S36-AL9-1.1 (15) | 0.41 (0.06) | ND | |
| S36-AL9-10.10 (1) | ||||
| B*15 | RLRPGGKKKY (Gag 20-29) | MO471-RY10-1.1 (5) | 0.89 (0.24) | ND |
| TQGYFPDWQNY (Nef 117-127) | 42 871-TY11-10.4 (5) | 0.34 (0.10) | 4.6 (0.2) | |
| 42 871-TY11-10.37 (2) | ||||
| B*40 | QELKNSAVNL (Env 805-814) | S82-QL10-1.6 (2) | 0.75 (0.12) | ND |
| KEKGGLEGL (Nef 92-100) | S16-KL9-4.1 (1) | 0.45 | ND | |
| B*57 | ISPRTLNAW (Gag 147-155) | S11-IW9-10.73 (5) | 0.52 (0.27) | 4.8 (0.3) |
| S11-IW9-3.5 (1) | ||||
| S11-IW9-10.68 (2) | ||||
| S11-IW9-10.65 (1) | ||||
| S14-IW9-3.14 (1) | ||||
| S14-IW9-3.21 (3) | ||||
| S14-IW9-10.15 (6) | ||||
| S36-IW9-10.37 (2) | ||||
| KAFSPEVIPMF (Gag 162-172) | S14-KF11-10.2 (10) | 0.60 (0.14) | 4.3 (0.2) | |
| S14-KF11-10.12 (2) | ||||
| S14-KF11-10.36 (2) | ||||
| S14-KF11-10.47 (5) | ||||
| S14-KF11-3.22 (9) | ||||
| S14-KF11-1.3 (5) | ||||
| S14-KF11-10.6 (1) | ||||
| TSTLQEQIGW (Gag 240-249) | S11-TW10-3.24 (2) | 0.97 (0.04) | 4.7 (0.7) | |
| S11-TW10-10.38 (7) | ||||
| S11-TW10-10.47 (3) | ||||
| QASQEVKNW (Gag 308-316) | S34-QW9-1.1 (1) | 0.96 (0.05) | 5.2 (0.8) | |
| S16-QW9-1.10 (1) | ||||
| S34-QW9-10.53 (1) | ||||
| HTQGYFPDWQ (Nef 116-125) | 42 871-HQ10-3.6 (4) | 0.52 (0.05) | 4.7 (1.1) | |
| S14-HQ10-1.1 (2) | ||||
| S14-HQ10-1.3 (3) | ||||
| S11-HQ10-10.10 (1) | ||||
| S11-HQ10-10.31 (2) | ||||
| YFPDWQNYT (Nef 120-128) | S14-YT9-1.2 (2) | 0.55 (0.09) | 5.9 | |
| S14-YT9-10.4 (2) | ||||
| S14-YT9-10.8 (1) | ||||
| S36-YT9-3.36 (2) | ||||
| KIATESIVIW (Pol 529-538) | S34-KW10-10.38 (6) | 0.28 (0.03) | 3.9 | |
| S34-KW10-10.55 (1) | ||||
| RTVRLIKLLY (Rev 14-23) | S36-RY10-3.20 (2) | 1.00 (0.29) | 4.9 | |
| S36-RY10-3.3 (4) | ||||
| S36-RY10-3.4 (2) | ||||
| S36-RY10-3.30 (1) |
| HLA . | Epitope (location) . | Clone (n)* . | Mean Nef-effect ratio (SD) . | Mean functional avidity (SD)† . |
|---|---|---|---|---|
| A*02 | SLYNTVATL (Gag 77-85) | S1-SL9-1.8 (11) | 0.54 (0.19) | 2.3 (0.6) |
| S1-SL9-1.7 (1) | ||||
| S1-SL9-3.23 (18) | ||||
| S36-SL9-1.9 (10) | ||||
| S36-SL9-10.18 (3) | ||||
| S31-SL9-10.11 (4) | ||||
| TLNAWVKVV (Gag 151-159) | S82-TV9-10.28 (2) | 0.73 (0.09) | 5.0 | |
| AAVDLSHFL (Nef 83-91) | S58-AL9-10.18 (2) | 0.46 | ND | |
| ILKEPVHGV (Pol 446-472) | 68A62-IV9 (8) | 0.46 (0.31) | 4.9 | |
| S31-IV9-10.4 (1) | ||||
| AIIRILQQL (Vpr 59-67) | S36-AL9-1.1 (15) | 0.41 (0.06) | ND | |
| S36-AL9-10.10 (1) | ||||
| B*15 | RLRPGGKKKY (Gag 20-29) | MO471-RY10-1.1 (5) | 0.89 (0.24) | ND |
| TQGYFPDWQNY (Nef 117-127) | 42 871-TY11-10.4 (5) | 0.34 (0.10) | 4.6 (0.2) | |
| 42 871-TY11-10.37 (2) | ||||
| B*40 | QELKNSAVNL (Env 805-814) | S82-QL10-1.6 (2) | 0.75 (0.12) | ND |
| KEKGGLEGL (Nef 92-100) | S16-KL9-4.1 (1) | 0.45 | ND | |
| B*57 | ISPRTLNAW (Gag 147-155) | S11-IW9-10.73 (5) | 0.52 (0.27) | 4.8 (0.3) |
| S11-IW9-3.5 (1) | ||||
| S11-IW9-10.68 (2) | ||||
| S11-IW9-10.65 (1) | ||||
| S14-IW9-3.14 (1) | ||||
| S14-IW9-3.21 (3) | ||||
| S14-IW9-10.15 (6) | ||||
| S36-IW9-10.37 (2) | ||||
| KAFSPEVIPMF (Gag 162-172) | S14-KF11-10.2 (10) | 0.60 (0.14) | 4.3 (0.2) | |
| S14-KF11-10.12 (2) | ||||
| S14-KF11-10.36 (2) | ||||
| S14-KF11-10.47 (5) | ||||
| S14-KF11-3.22 (9) | ||||
| S14-KF11-1.3 (5) | ||||
| S14-KF11-10.6 (1) | ||||
| TSTLQEQIGW (Gag 240-249) | S11-TW10-3.24 (2) | 0.97 (0.04) | 4.7 (0.7) | |
| S11-TW10-10.38 (7) | ||||
| S11-TW10-10.47 (3) | ||||
| QASQEVKNW (Gag 308-316) | S34-QW9-1.1 (1) | 0.96 (0.05) | 5.2 (0.8) | |
| S16-QW9-1.10 (1) | ||||
| S34-QW9-10.53 (1) | ||||
| HTQGYFPDWQ (Nef 116-125) | 42 871-HQ10-3.6 (4) | 0.52 (0.05) | 4.7 (1.1) | |
| S14-HQ10-1.1 (2) | ||||
| S14-HQ10-1.3 (3) | ||||
| S11-HQ10-10.10 (1) | ||||
| S11-HQ10-10.31 (2) | ||||
| YFPDWQNYT (Nef 120-128) | S14-YT9-1.2 (2) | 0.55 (0.09) | 5.9 | |
| S14-YT9-10.4 (2) | ||||
| S14-YT9-10.8 (1) | ||||
| S36-YT9-3.36 (2) | ||||
| KIATESIVIW (Pol 529-538) | S34-KW10-10.38 (6) | 0.28 (0.03) | 3.9 | |
| S34-KW10-10.55 (1) | ||||
| RTVRLIKLLY (Rev 14-23) | S36-RY10-3.20 (2) | 1.00 (0.29) | 4.9 | |
| S36-RY10-3.3 (4) | ||||
| S36-RY10-3.4 (2) | ||||
| S36-RY10-3.30 (1) |