Iron and inflammatory markers and erythrocyte stable isotope iron incorporation in Gambian children presenting with either postmalarial or nonmalarial anemia, and supplemented with iron for 30 days
| . | Status on day 1: day of 57Fe oral administration . | Status on day 15: day of 58Fe oral administration . | ||
|---|---|---|---|---|
| Postmalarial anemia . | Nonmalarial anemia . | Postmalarial anemia . | Nonmalarial anemia . | |
| N | 11 | 16 | 11 | 16 |
| span class=SpellEHb, g/L | 84 ± 3 | 95 ± 3* | 105 ± 4† | 98 ± 2 |
| Hepcidin, ng/mL | 25.5 ± 7.4 | 12.8 ± 5.8 | 16.3 ± 5.2 | 17.5 ± 4.7 |
| CRP, mg/L | 54 (30, 84) | 4 (2, 6)‡ | 7 (2, 15)† | 4 (2, 6) |
| Ferritin, ng/mL | 82 (48, 164) | 5 (3, 7)‡ | 25 (17, 33)† | 14 (8, 20)§ |
| Serum iron, μmol/L | 16.0 ± 1.9 | 10.9 ± 0.8‖ | 14.6 ± 1.2 | 14.3 ± 1.2¶ |
| sTfR, mg/L | 6.6 ± 0.7 | 9.3 ± 0.9* | 8.3 ± 0.6† | 7.7 ± 0.9¶ |
| sTfR-F index | 4.8 ± 1.8 | 22.9 ± 8.3* | 7.1 ± 0.7 | 7.7 ± 0.9 |
| Erythropoeitin, mIU/mL | 70 (34, 120) | 23 (3, 55)* | 10 (8, 12)¶ | 14 (8, 20)¶ |
| ZnPP, mmol/mol Hb | 131 (103, 159) | 131 (105, 171) | 117 (87, 148) | 132 (106, 162) |
| Stable iron isotope incorporation 14 days after oral administration (%) | 10.6 ± 3.5 | 25.4 ± 3.9‖ | 22.8 ± 4.8† | 30.3 ± 4.8 |
| . | Status on day 1: day of 57Fe oral administration . | Status on day 15: day of 58Fe oral administration . | ||
|---|---|---|---|---|
| Postmalarial anemia . | Nonmalarial anemia . | Postmalarial anemia . | Nonmalarial anemia . | |
| N | 11 | 16 | 11 | 16 |
| span class=SpellEHb, g/L | 84 ± 3 | 95 ± 3* | 105 ± 4† | 98 ± 2 |
| Hepcidin, ng/mL | 25.5 ± 7.4 | 12.8 ± 5.8 | 16.3 ± 5.2 | 17.5 ± 4.7 |
| CRP, mg/L | 54 (30, 84) | 4 (2, 6)‡ | 7 (2, 15)† | 4 (2, 6) |
| Ferritin, ng/mL | 82 (48, 164) | 5 (3, 7)‡ | 25 (17, 33)† | 14 (8, 20)§ |
| Serum iron, μmol/L | 16.0 ± 1.9 | 10.9 ± 0.8‖ | 14.6 ± 1.2 | 14.3 ± 1.2¶ |
| sTfR, mg/L | 6.6 ± 0.7 | 9.3 ± 0.9* | 8.3 ± 0.6† | 7.7 ± 0.9¶ |
| sTfR-F index | 4.8 ± 1.8 | 22.9 ± 8.3* | 7.1 ± 0.7 | 7.7 ± 0.9 |
| Erythropoeitin, mIU/mL | 70 (34, 120) | 23 (3, 55)* | 10 (8, 12)¶ | 14 (8, 20)¶ |
| ZnPP, mmol/mol Hb | 131 (103, 159) | 131 (105, 171) | 117 (87, 148) | 132 (106, 162) |
| Stable iron isotope incorporation 14 days after oral administration (%) | 10.6 ± 3.5 | 25.4 ± 3.9‖ | 22.8 ± 4.8† | 30.3 ± 4.8 |
Arithmetic means ± SE or geometric means (95% CI).
Hb indicates hemoglobin; CRP, C-reactive protein; sTfR, soluble transferrin receptor; ZnPP, zinc protoporphyrin; and CI, confidence interval.
P < .05 by unpaired t test comparing postmalarial to nonmalarial anemia groups.
P < .01 by Scheffé posthoc test day 15 vs day 1.
P < .001 by unpaired t test comparing postmalarial to nonmalarial anemia groups.
P < .001 by Scheffé posthoc test day 15 vs day 1.
P < .01 by unpaired t test comparing postmalarial to nonmalarial anemia groups.
P < .05 by Scheffé posthoc test day 15 vs day 1.