Vector biodistribution in selected rhesus monkey tissues following in utero and postnatal readministration of scAAV-LP1-FVII-coop
| Tissue . | Viral genome copies per cell . |
|---|---|
| BM | 0.38 |
| Cerebellum | 0.02 |
| Jejunum | 0.03 |
| Left ventricle | 2.65 |
| Liver caudate | 35.89 |
| Liver left lateral | 9.35 |
| Liver right lateral | 41.86 |
| Lung right middle | 1.94 |
| Right adrenal gland | 1.05 |
| Right axial lymph node | 0.03 |
| Right ovary | 4.53 |
| Spinal cord | 0.045 |
| Spleen | 0.40 |
| Naive liver | 0.00 |
| Water | 0.00 |
| Tissue . | Viral genome copies per cell . |
|---|---|
| BM | 0.38 |
| Cerebellum | 0.02 |
| Jejunum | 0.03 |
| Left ventricle | 2.65 |
| Liver caudate | 35.89 |
| Liver left lateral | 9.35 |
| Liver right lateral | 41.86 |
| Lung right middle | 1.94 |
| Right adrenal gland | 1.05 |
| Right axial lymph node | 0.03 |
| Right ovary | 4.53 |
| Spinal cord | 0.045 |
| Spleen | 0.40 |
| Naive liver | 0.00 |
| Water | 0.00 |
Rhesus monkeys were injected in utero with 4 × 1011 vg/kg scAAV5-LP1-hFVII-coop near term, and administered a second dose of 4 × 1011 vg scAAV8-LP1-hFVII-coop IV 1 year after birth. Tissue samples were collected at ∼ 1.5 years of age and viral genome copy number per cell was quantified by quantitative PCR.