Table 2 Leukocyte subset analysis in the... | American Society of Hematology

Table 2

Leukocyte subset analysis in the blood of 3 patients with WHIM syndrome caused by missense mutation CXCR4^E343K

Cell type	P1	P2	P3	Reference range for children, cells/μL of blood, mean*	Reference range for adults, cells/μL of blood, mean†
CD3⁺ T cell	*943*	1487	*700*	1200-2600	714-2266
CD4⁺ T cell	*478*	903	512	650-1500	359-1565
CD4⁺ CD45RA⁺ naive T cell	*261*	630	54	320-1000	454-733
CD4⁺ CD45RO⁺ memory T cell	*149*	*147*	392	230-630	219-1048
CD4⁺ CD45RA⁻ CD62L⁺ CCR7⁺ central memory T cell	4	8	13	ND	16-49
CD4⁺ CD45RA⁻CD62L⁻ CCR7⁻ effector memory T cell	32	32	88	ND	57-130
CD8⁺ T cell	*347*	449	*161*	370-1100	178-853
CD8⁺CD45RA⁺ naive T cell	*172*	360	66	310-900	231-371
CD8⁺CD45RO⁺ memory T cell	26	20	30	70-390	50-352
CD8⁺CD45RA⁻CD62L⁺CCR7⁺ central memory T cell	< 1	< 1	< 1	ND	0-12
CD8⁺CD45RA⁻CD62L⁻CCR7⁻ effector memory T cell	7	21	10	ND	22-75
CD3⁻CD56⁺ NK cell	161	77	59	100-480	126-729
CD19⁺ B cell	*127*	414	152	270-860	61-329
CD19⁺CD27⁺ memory B cell	39	135	34	60-230	12-68
CD19⁺CD27⁺CD38⁺IgD⁺ unswitched memory B cell	1	1	2	ND	0-2
CD19⁺CD27⁺CD38⁺IgD⁻ switched memory B cell	7	5	3	ND	4-21
CD19⁺CD27⁻ B cell	53	71	118	140-470	90-176
CD19⁺CD27⁻IgD⁺IgM⁺ transitional/naive B cell	28	43	69	ND	42-85
CD19⁺CD27⁻IgD⁻IgM⁺ immature B cell	< 1	< 1	3	ND	2-10
CD14⁺CD16⁻ classical monocyte	*195*	*264*	*147*	527-595	371-539
CD14⁺CD16⁺ inflammatory monocyte	5	6	13	80-106	14-30

Cell type	P1	P2	P3	Reference range for children, cells/μL of blood, mean*	Reference range for adults, cells/μL of blood, mean†
CD3⁺ T cell	*943*	1487	*700*	1200-2600	714-2266
CD4⁺ T cell	*478*	903	512	650-1500	359-1565
CD4⁺ CD45RA⁺ naive T cell	*261*	630	54	320-1000	454-733
CD4⁺ CD45RO⁺ memory T cell	*149*	*147*	392	230-630	219-1048
CD4⁺ CD45RA⁻ CD62L⁺ CCR7⁺ central memory T cell	4	8	13	ND	16-49
CD4⁺ CD45RA⁻CD62L⁻ CCR7⁻ effector memory T cell	32	32	88	ND	57-130
CD8⁺ T cell	*347*	449	*161*	370-1100	178-853
CD8⁺CD45RA⁺ naive T cell	*172*	360	66	310-900	231-371
CD8⁺CD45RO⁺ memory T cell	26	20	30	70-390	50-352
CD8⁺CD45RA⁻CD62L⁺CCR7⁺ central memory T cell	< 1	< 1	< 1	ND	0-12
CD8⁺CD45RA⁻CD62L⁻CCR7⁻ effector memory T cell	7	21	10	ND	22-75
CD3⁻CD56⁺ NK cell	161	77	59	100-480	126-729
CD19⁺ B cell	*127*	414	152	270-860	61-329
CD19⁺CD27⁺ memory B cell	39	135	34	60-230	12-68
CD19⁺CD27⁺CD38⁺IgD⁺ unswitched memory B cell	1	1	2	ND	0-2
CD19⁺CD27⁺CD38⁺IgD⁻ switched memory B cell	7	5	3	ND	4-21
CD19⁺CD27⁻ B cell	53	71	118	140-470	90-176
CD19⁺CD27⁻IgD⁺IgM⁺ transitional/naive B cell	28	43	69	ND	42-85
CD19⁺CD27⁻IgD⁻IgM⁺ immature B cell	< 1	< 1	3	ND	2-10
CD14⁺CD16⁻ classical monocyte	*195*	*264*	*147*	527-595	371-539
CD14⁺CD16⁺ inflammatory monocyte	5	6	13	80-106	14-30

Values below the appropriate reference range are bolded and italicized.

Based on the reported values from healthy children.^44-46

Based on values from 11-40 healthy adults in our clinical center.

ND indicates not defined.