Guidelines for laboratory monitoring of disease activity
| CBC with differential . | Every mo . |
|---|---|
| Bone marrow with cytogenetics/FISH | Every 3 mo until CCyR |
| Peripheral blood quantitative PCR for BCR-ABL | Every 3 mo until MMR, then every 6 mo |
| TKI mutation analysis | Any measure of suboptimal response: failure to reach or maintain CHR, CCyR, or MMR; rise in quantitative PCR after MMR; or increase in Ph+ chromosomes if CCyR not obtained |
| CBC with differential . | Every mo . |
|---|---|
| Bone marrow with cytogenetics/FISH | Every 3 mo until CCyR |
| Peripheral blood quantitative PCR for BCR-ABL | Every 3 mo until MMR, then every 6 mo |
| TKI mutation analysis | Any measure of suboptimal response: failure to reach or maintain CHR, CCyR, or MMR; rise in quantitative PCR after MMR; or increase in Ph+ chromosomes if CCyR not obtained |