Definition of clinical response to treatment40,41
| Hematologic response: CBC . | Cytogenetic response: Ph+ metaphases . | Molecular response: Bcr-Abl transcripts . |
|---|---|---|
| Complete: WBC < 10 × 103/L, platelets < 450 × 109/L, and differential with no immature granulocytes and < 5% basophils | Complete: 0% | Complete: transcripts not detectable, or > 3-log reduction in transcript from diagnosis |
| Partial: 1%-35% | Major: < 0.1% | |
| Minor: 36%-65% | ||
| Minimal: 66%-95% |
| Hematologic response: CBC . | Cytogenetic response: Ph+ metaphases . | Molecular response: Bcr-Abl transcripts . |
|---|---|---|
| Complete: WBC < 10 × 103/L, platelets < 450 × 109/L, and differential with no immature granulocytes and < 5% basophils | Complete: 0% | Complete: transcripts not detectable, or > 3-log reduction in transcript from diagnosis |
| Partial: 1%-35% | Major: < 0.1% | |
| Minor: 36%-65% | ||
| Minimal: 66%-95% |