Risk of radiation-associated breast cancer associated with rs1219648 in Hodgkin lymphoma patients
| Genotype . | Discovery . | Replication . | Combined . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Breast cancer in HL patient . | OR (95% CI) . | P . | Breast cancer in HL patient . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| + . | − . | + . | − . | |||||||
| AA | 41 | 132 | 1.00 | — | 29 | 57 | 1.00 | 1.00 | — | |
| AG | 68 | 146 | 1.50 (0.95-2.36) | .08 | 45 | 78 | 1.13 (0.64-2.02) | .67 | 1.35 (0.94-1.93) | .10 |
| GG | 31 | 31 | 3.22 (1.75-5.92) | .000167 | 18 | 17 | 2.08 (0.94-4.63) | .072 | 2.74 (1.69-4.45) | .000444 |
| Per allele | 1.73 (1.29-2.34) | .000273 | 1.37 (0.93-2.02) | .11 | 1.59 (1.26-2.02) | .000111 | ||||
| Genotype . | Discovery . | Replication . | Combined . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Breast cancer in HL patient . | OR (95% CI) . | P . | Breast cancer in HL patient . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| + . | − . | + . | − . | |||||||
| AA | 41 | 132 | 1.00 | — | 29 | 57 | 1.00 | 1.00 | — | |
| AG | 68 | 146 | 1.50 (0.95-2.36) | .08 | 45 | 78 | 1.13 (0.64-2.02) | .67 | 1.35 (0.94-1.93) | .10 |
| GG | 31 | 31 | 3.22 (1.75-5.92) | .000167 | 18 | 17 | 2.08 (0.94-4.63) | .072 | 2.74 (1.69-4.45) | .000444 |
| Per allele | 1.73 (1.29-2.34) | .000273 | 1.37 (0.93-2.02) | .11 | 1.59 (1.26-2.02) | .000111 | ||||
OR indicates odds ratio; CI, confidence interval; and —, not applicable.