Multivariate analysis restricted to haploidentical HCT using BM grafts vs unrelated donor transplants using PB grafts only
| . | No. . | Relative risk . | 95% CI lower limit . | 95% CI upper limit . | P . | Overall P . |
|---|---|---|---|---|---|---|
| Acute GVHD (grades 2-4) | ||||||
| Haploidentical | 167 | 1 | .32 | |||
| URD without ATG | 451 | 1.30 | 0.90 | 1.89 | .16 | |
| URD with ATG | 213 | 1.34 | 0.88 | 2.06 | .17 | |
| Acute GVHD (grades 3-4) | ||||||
| Haploidentical | 167 | 1 | .005 | |||
| URD without ATG | 451 | 2.41 | 1.27 | 4.57 | .007 | |
| URD with ATG | 213 | 2.2 | 1.09 | 4.43 | .03 | |
| Chronic GVHD | ||||||
| Haploidentical | 170 | 1 | <.0001 | |||
| URD without ATG | 446 | 6.72 | 4.39 | 10.31 | <.0001 | |
| URD with ATG | 208 | 4.44 | 2.78 | 7.08 | <.0001 | |
| Contrast | ||||||
| URD without ATG vs URD with ATG | 1.51 | 1.17 | 1.95 | .001 | ||
| NRM | ||||||
| Haploidentical | 171 | 1 | .051 | |||
| URD without ATG | 457 | 1.04 | 0.67 | 1.62 | .84 | |
| URD with ATG | 216 | 1.56 | 0.97 | 2.5 | .06 | |
| Contrast | ||||||
| URD without ATG vs URD with ATG | 0.67 | 0.47 | 0.95 | .02 | ||
| Progression/relapse | ||||||
| Haploidentical | 171 | 1 | .30 | |||
| URD without ATG | 457 | 0.78 | 0.57 | 1.07 | .12 | |
| URD with ATG | 214 | 0.86 | 0.60 | 1.22 | .40 | |
| PFS | ||||||
| Main effect | ||||||
| Haploidentical | 171 | 1 | .16 | |||
| URD without ATG | 457 | 0.87 | 0.68 | 1.13 | .30 | |
| URD with ATG | 216 | 1.08 | 0.81 | 1.43 | .60 | |
| OS | ||||||
| Haploidentical | 172 | 1 | .02 | |||
| URD without ATG | 460 | 0.82 | 0.61 | 1.11 | .21 | |
| URD with ATG | 217 | 1.17 | 0.85 | 1.62 | .33 | |
| Contrast | ||||||
| URD without ATG vs URD with ATG | 0.70 | 0.54 | 0.91 | .007 |
| . | No. . | Relative risk . | 95% CI lower limit . | 95% CI upper limit . | P . | Overall P . |
|---|---|---|---|---|---|---|
| Acute GVHD (grades 2-4) | ||||||
| Haploidentical | 167 | 1 | .32 | |||
| URD without ATG | 451 | 1.30 | 0.90 | 1.89 | .16 | |
| URD with ATG | 213 | 1.34 | 0.88 | 2.06 | .17 | |
| Acute GVHD (grades 3-4) | ||||||
| Haploidentical | 167 | 1 | .005 | |||
| URD without ATG | 451 | 2.41 | 1.27 | 4.57 | .007 | |
| URD with ATG | 213 | 2.2 | 1.09 | 4.43 | .03 | |
| Chronic GVHD | ||||||
| Haploidentical | 170 | 1 | <.0001 | |||
| URD without ATG | 446 | 6.72 | 4.39 | 10.31 | <.0001 | |
| URD with ATG | 208 | 4.44 | 2.78 | 7.08 | <.0001 | |
| Contrast | ||||||
| URD without ATG vs URD with ATG | 1.51 | 1.17 | 1.95 | .001 | ||
| NRM | ||||||
| Haploidentical | 171 | 1 | .051 | |||
| URD without ATG | 457 | 1.04 | 0.67 | 1.62 | .84 | |
| URD with ATG | 216 | 1.56 | 0.97 | 2.5 | .06 | |
| Contrast | ||||||
| URD without ATG vs URD with ATG | 0.67 | 0.47 | 0.95 | .02 | ||
| Progression/relapse | ||||||
| Haploidentical | 171 | 1 | .30 | |||
| URD without ATG | 457 | 0.78 | 0.57 | 1.07 | .12 | |
| URD with ATG | 214 | 0.86 | 0.60 | 1.22 | .40 | |
| PFS | ||||||
| Main effect | ||||||
| Haploidentical | 171 | 1 | .16 | |||
| URD without ATG | 457 | 0.87 | 0.68 | 1.13 | .30 | |
| URD with ATG | 216 | 1.08 | 0.81 | 1.43 | .60 | |
| OS | ||||||
| Haploidentical | 172 | 1 | .02 | |||
| URD without ATG | 460 | 0.82 | 0.61 | 1.11 | .21 | |
| URD with ATG | 217 | 1.17 | 0.85 | 1.62 | .33 | |
| Contrast | ||||||
| URD without ATG vs URD with ATG | 0.70 | 0.54 | 0.91 | .007 |