Table 3

Multivariate analysis results

No.No. of eventsRR95% CI lower limit95% CI upper limitPOverall P
Acute GVHD (grades 2-4)*        
 Haploidentical 180 68 1    .47 
 URD without ATG 482 206 1.22 0.86 1.74 .27  
 URD with ATG 235 104 1.26 0.84 1.89 .25  
Acute GVHD (grades 3-4)*        
 Haploidentical 180 12 1    .005 
 URD without ATG 482 82 2.87 1.52 5.40 .001  
 URD with ATG 235 35 2.45 1.23 4.87 .01  
 Contrast        
  URD without ATG vs URD with ATG   1.17 0.76 1.80 .47  
Chronic GVHD        
 Haploidentical 183 28 1    <.0001 
 URD without ATG 475 289 5.85 3.96 8.64 <.0001  
 URD with ATG 230 82 3.64 2.37 5.60 <.0001  
 Contrast        
  URD without ATG vs URD with ATG   1.61 1.25 2.05 .0002  
NRM        
 Haploidentical 184 32 1    .04 
 URD without ATG 488 98 1.03 0.68 1.56 .88  
 URD with ATG 240 60 1.54 0.98 2.4 .06  
Progression/relapse        
 Haploidentical 184 65 1    .27 
 URD without ATG 488 137 0.8 0.59 1.08 .15  
 URD with ATG 238 80 0.95 0.67 1.33 .75  
 Contrast        
  URD without ATG vs URD with ATG   0.85 0.64 1.12 .24  
PFS        
 Haploidentical 184 97 1    .08 
 URD without ATG 488 235 0.90 0.71 1.16 .42  
 URD with ATG 240 140 1.16 0.88 1.51 .29  
 Contrast        
  URD without ATG vs URD w/ATG   0.78 0.63 0.97 .02  
OS        
 Haploidentical 185 76 1    .004 
 URD without ATG 491 171 0.83 0.62 1.11 .21  
 URD with ATG 241 113 1.25 0.92 1.69 .16  
 Contrast        
  URD without ATG vs URD with ATG   0.67 0.52 0.85 .001  
No.No. of eventsRR95% CI lower limit95% CI upper limitPOverall P
Acute GVHD (grades 2-4)*        
 Haploidentical 180 68 1    .47 
 URD without ATG 482 206 1.22 0.86 1.74 .27  
 URD with ATG 235 104 1.26 0.84 1.89 .25  
Acute GVHD (grades 3-4)*        
 Haploidentical 180 12 1    .005 
 URD without ATG 482 82 2.87 1.52 5.40 .001  
 URD with ATG 235 35 2.45 1.23 4.87 .01  
 Contrast        
  URD without ATG vs URD with ATG   1.17 0.76 1.80 .47  
Chronic GVHD        
 Haploidentical 183 28 1    <.0001 
 URD without ATG 475 289 5.85 3.96 8.64 <.0001  
 URD with ATG 230 82 3.64 2.37 5.60 <.0001  
 Contrast        
  URD without ATG vs URD with ATG   1.61 1.25 2.05 .0002  
NRM        
 Haploidentical 184 32 1    .04 
 URD without ATG 488 98 1.03 0.68 1.56 .88  
 URD with ATG 240 60 1.54 0.98 2.4 .06  
Progression/relapse        
 Haploidentical 184 65 1    .27 
 URD without ATG 488 137 0.8 0.59 1.08 .15  
 URD with ATG 238 80 0.95 0.67 1.33 .75  
 Contrast        
  URD without ATG vs URD with ATG   0.85 0.64 1.12 .24  
PFS        
 Haploidentical 184 97 1    .08 
 URD without ATG 488 235 0.90 0.71 1.16 .42  
 URD with ATG 240 140 1.16 0.88 1.51 .29  
 Contrast        
  URD without ATG vs URD w/ATG   0.78 0.63 0.97 .02  
OS        
 Haploidentical 185 76 1    .004 
 URD without ATG 491 171 0.83 0.62 1.11 .21  
 URD with ATG 241 113 1.25 0.92 1.69 .16  
 Contrast        
  URD without ATG vs URD with ATG   0.67 0.52 0.85 .001  
*

Acute GVHD models used logistic regression.

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