Table 1 Summary of body weight... | American Society of Hematology

Table 1

Summary of body weight development, hematology, and serum chemistry of rhVWF-challenged ADAMTS13 KO mice

Variable	Time point, d	TTP model
		2000 U/kg rhVWF*			Untreated
		Mean	%	n†	Mean‡	n†
Platelets, × 10³/μL	1	30	2.7	28	1128 (overall)	41
	3	416	36.9	13
	14	1276	113.1	10
Body weight, Δ%	0-1	−8.8	NA	40	−0.9	33
	0-3	−4.8		13	−0.9	10
	0-14	0.1		10	0.8	10
Hematocrit, %	1	34.6	85.2	28	40.6 (overall)	41
	3	28.5	70.2	13
	14	41.7	102.7	10
LDH, U/L	1	1598	482.8	12	331	12
Schistocytes, 1000 RBCs	1	27.5	9166.7	29	0.3	20

Variable	Time point, d	TTP model
		2000 U/kg rhVWF*			Untreated
		Mean	%	n†	Mean‡	n†
Platelets, × 10³/μL	1	30	2.7	28	1128 (overall)	41
	3	416	36.9	13
	14	1276	113.1	10
Body weight, Δ%	0-1	−8.8	NA	40	−0.9	33
	0-3	−4.8		13	−0.9	10
	0-14	0.1		10	0.8	10
Hematocrit, %	1	34.6	85.2	28	40.6 (overall)	41
	3	28.5	70.2	13
	14	41.7	102.7	10
LDH, U/L	1	1598	482.8	12	331	12
Schistocytes, 1000 RBCs	1	27.5	9166.7	29	0.3	20

NA indicates not applicable.

U rhVWF = VWF:RCoU rhVWF.

Number of reported values can be smaller than group size because of missing values (eg, technical errors).

Means of untreated animals are set to 100% to compare means of rhVWF-challenged animals.