Recently completed and ongoing studies targeting inflammation
| Study title . | Clinical trials #/Phase . | Intervention . | Status . | Primary sponsor . |
|---|---|---|---|---|
| Adenosine and invariant NK T (iNKT) cells | ||||
| Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease | NCT01085201 Phase 1 | Regadenoson | Complete | Dana-Farber Cancer Institute |
| A Phase II Trial of Regadenoson in Sickle Cell Anemia | NCT01788631 Phase 2 | Regadenoson | Ongoing | Dana-Farber Cancer Institute |
| Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD) | NCT01783691 Phase 1 | NKTT120 | Complete | NKT Therapeutics |
| Leukotrienes | ||||
| Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia | NCT01960413 Phase 2 | Montelukast | Ongoing | Vanderbilt Univ. |
| Trial of Zileuton CR in Children and Adults With Sickle Cell Disease | NCT01136941 Phase 1 | Zileuton | Complete | Children's Hospital Medical Center, Cincinnati |
| Neutrophil adhesion and non-specific anti-inflammatory reagents | ||||
| Intravenous Gammaglobulin for Sickle Cell Pain Crises | NCT01757418 Phase 1/2 | IVIg | Ongoing | A. Einstein College of Medicine, Yeshiva Univ. |
| Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease | NCT01702246 Phase 2 | Simvastatin | Ongoing | Children's Hospital & Research Center Oakland |
| Study title . | Clinical trials #/Phase . | Intervention . | Status . | Primary sponsor . |
|---|---|---|---|---|
| Adenosine and invariant NK T (iNKT) cells | ||||
| Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease | NCT01085201 Phase 1 | Regadenoson | Complete | Dana-Farber Cancer Institute |
| A Phase II Trial of Regadenoson in Sickle Cell Anemia | NCT01788631 Phase 2 | Regadenoson | Ongoing | Dana-Farber Cancer Institute |
| Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD) | NCT01783691 Phase 1 | NKTT120 | Complete | NKT Therapeutics |
| Leukotrienes | ||||
| Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia | NCT01960413 Phase 2 | Montelukast | Ongoing | Vanderbilt Univ. |
| Trial of Zileuton CR in Children and Adults With Sickle Cell Disease | NCT01136941 Phase 1 | Zileuton | Complete | Children's Hospital Medical Center, Cincinnati |
| Neutrophil adhesion and non-specific anti-inflammatory reagents | ||||
| Intravenous Gammaglobulin for Sickle Cell Pain Crises | NCT01757418 Phase 1/2 | IVIg | Ongoing | A. Einstein College of Medicine, Yeshiva Univ. |
| Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease | NCT01702246 Phase 2 | Simvastatin | Ongoing | Children's Hospital & Research Center Oakland |