Table 3

Subgroup analysis and tests for interaction

NDeadOS
EFS
−G-CSF (5-y), %+G-CSF (5-y), %HR95% CIPEvent−G-CSF (5-y), %+G-CSF (5-y), %HR95% CIP
Total 917 509 40 43 0.99 0.83-1.17 .88 589 31 37 0.92 0.78-1.08 29 
Age, y       P-int = .24      P-int = .35 
    ≤ 35 165 81 43 55 0.77 0.50-1.20 .24 94 32 50 0.70 0.46-1.05 .088 
    36-50 339 174 47 43 1.19 0.88-1.60 .26 208 37 38 0.99 0.75-1.30 .94 
    > 50 413 254 33 39 0.94 0.74-1.21 .64 287 26 30 0.95 0.75-1.20 .67 
WBC       P-int = .71      P-int = .39 
    ≤ 20 × 109/L              
    20-100 × 109/L 550 293 43 48 0.97 0.77-1.22 .80 350 32 39 0.91 0.74-1.13 .41 
    > 100 × 109/L 262 143 39 43 0.94 0.68-1.31 .73 161 35 39 0.84 0.61-1.14 .26 
    ≤ 20 × 109/L 105 73 27 25 1.18 0.75-1.88 .47 78 23 22 1.22 0.78-1.90 .39 
Cytogenetics       P-int = .82      P-int = .52 
    CBF 94 27 72 63 1.05 0.49-2.25 .90 42 51 52 0.83 0.45-1.52 .55 
    Rest 707 376 42 46 1.01 0.82-1.24 .93 440 33 39 0.95 0.78-1.14 .56 
    MK 116 106 6 8 0.88 0.60-1.29 .52 107 6 10 0.74 0.51-1.09 .13 
Ara-C dose       P-int < .001      P-int = .023 
    Conventional 709 382 43 41 1.16 0.95-1.42 .14 451 33 35 1.02 0.85-1.22 .86 
    Escalated 207 126 30 50 0.59 0.41-0.84 .003 137 28 43 0.65 0.46-0.91 .012 
NDeadOS
EFS
−G-CSF (5-y), %+G-CSF (5-y), %HR95% CIPEvent−G-CSF (5-y), %+G-CSF (5-y), %HR95% CIP
Total 917 509 40 43 0.99 0.83-1.17 .88 589 31 37 0.92 0.78-1.08 29 
Age, y       P-int = .24      P-int = .35 
    ≤ 35 165 81 43 55 0.77 0.50-1.20 .24 94 32 50 0.70 0.46-1.05 .088 
    36-50 339 174 47 43 1.19 0.88-1.60 .26 208 37 38 0.99 0.75-1.30 .94 
    > 50 413 254 33 39 0.94 0.74-1.21 .64 287 26 30 0.95 0.75-1.20 .67 
WBC       P-int = .71      P-int = .39 
    ≤ 20 × 109/L              
    20-100 × 109/L 550 293 43 48 0.97 0.77-1.22 .80 350 32 39 0.91 0.74-1.13 .41 
    > 100 × 109/L 262 143 39 43 0.94 0.68-1.31 .73 161 35 39 0.84 0.61-1.14 .26 
    ≤ 20 × 109/L 105 73 27 25 1.18 0.75-1.88 .47 78 23 22 1.22 0.78-1.90 .39 
Cytogenetics       P-int = .82      P-int = .52 
    CBF 94 27 72 63 1.05 0.49-2.25 .90 42 51 52 0.83 0.45-1.52 .55 
    Rest 707 376 42 46 1.01 0.82-1.24 .93 440 33 39 0.95 0.78-1.14 .56 
    MK 116 106 6 8 0.88 0.60-1.29 .52 107 6 10 0.74 0.51-1.09 .13 
Ara-C dose       P-int < .001      P-int = .023 
    Conventional 709 382 43 41 1.16 0.95-1.42 .14 451 33 35 1.02 0.85-1.22 .86 
    Escalated 207 126 30 50 0.59 0.41-0.84 .003 137 28 43 0.65 0.46-0.91 .012 

N indicates number of patients; Dead, number of deaths; Event, number of events (no CR, relapse, or death in CR1); HR, hazard rate; CI, confidence interval; P-int, P value for test of interaction between factor and G-CSF treatment group; and P, other P values for test of no difference between G-CSF groups within row subgroup.

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