Results of SOX11 and p53 analysis in consecutive samples of initially SOX11− MCL
| Patient . | Diagnostic tissue . | Consecutive sample 1 . | Consecutive sample 2 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Source . | SOX11 . | p53 . | Source . | SOX11 . | p53 . | Source . | SOX11 . | p53 . | |
| 2 | LN | Neg | 0 | BM, same year | Neg | 0 | |||
| 15 | Stomach | Neg | 0 | BM, same year | Neg | 0 | New biopsy from stomach same year | Neg | 0 |
| 23 | LN | Neg | 0 | BM, same year | Pos | 0 | Stomach, 1 y after diagnosis | Weakly pos | 0 |
| 30 | LN | Neg | 1 | BM, same year | Neg, very few cells weakly pos | 1 | BM, same year | Neg, very few cells weakly pos | 1 |
| 32 | Spleen | Neg | 1 | BM, previous year | Few cells pos | 1 | BM, same year | Pos | 1 |
| 92 | BM | Neg | 1 | Tonsil, 1 y after diagnosis | Weakly pos | 1 | Shoulder, 1 y after diagnosis | Pos | 1 |
| 101 | Spleen | Neg | 1 | BM, 1 y after diagnosis | Neg | 1 | |||
| 104 | BM | Neg | 1 | BM, 1 y after diagnosis | Neg, very few cells weakly pos | 1 | BM, 1 y after diagnosis | Neg | |
| 123 | BM | Neg | 1 | Pleural biopsy, 1 y after diagnosis | Weakly pos | 1 | |||
| 139 | BM | Neg | 1 | Blood, 2 y after diagnosis | Neg | Duodenum, 3 y after diagnosis | ND | 1 | |
| 167 | LN | Neg | 0 | BM, same year | Neg | 0 | BM, 1 y after diagnosis | Neg | 1 |
| Patient . | Diagnostic tissue . | Consecutive sample 1 . | Consecutive sample 2 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Source . | SOX11 . | p53 . | Source . | SOX11 . | p53 . | Source . | SOX11 . | p53 . | |
| 2 | LN | Neg | 0 | BM, same year | Neg | 0 | |||
| 15 | Stomach | Neg | 0 | BM, same year | Neg | 0 | New biopsy from stomach same year | Neg | 0 |
| 23 | LN | Neg | 0 | BM, same year | Pos | 0 | Stomach, 1 y after diagnosis | Weakly pos | 0 |
| 30 | LN | Neg | 1 | BM, same year | Neg, very few cells weakly pos | 1 | BM, same year | Neg, very few cells weakly pos | 1 |
| 32 | Spleen | Neg | 1 | BM, previous year | Few cells pos | 1 | BM, same year | Pos | 1 |
| 92 | BM | Neg | 1 | Tonsil, 1 y after diagnosis | Weakly pos | 1 | Shoulder, 1 y after diagnosis | Pos | 1 |
| 101 | Spleen | Neg | 1 | BM, 1 y after diagnosis | Neg | 1 | |||
| 104 | BM | Neg | 1 | BM, 1 y after diagnosis | Neg, very few cells weakly pos | 1 | BM, 1 y after diagnosis | Neg | |
| 123 | BM | Neg | 1 | Pleural biopsy, 1 y after diagnosis | Weakly pos | 1 | |||
| 139 | BM | Neg | 1 | Blood, 2 y after diagnosis | Neg | Duodenum, 3 y after diagnosis | ND | 1 | |
| 167 | LN | Neg | 0 | BM, same year | Neg | 0 | BM, 1 y after diagnosis | Neg | 1 |
SOX11 staining was considered weak when the nuclear positivity was only discerned at 40× magnification, whereas strong positivity was seen also at low magnifications.
MCL indicates mantle cell lymphoma; LN, lymph node; BM, bone marrow; 0, negative; 1, positive; and ND, not done.