Comparison of peripheral blood white cell counts between rIL-5 treated and control EAN rats
| . | Day 0 . | Day 14 . | Day 21 . | Day 28 . | |||
|---|---|---|---|---|---|---|---|
| Normal . | rIL-5 Rx . | Control . | rIL-5 Rx . | Control . | rIL-5 Rx . | Control . | |
| WBC count | 12.8 ± 4 | 14.1 ± 4.1 | 13.6 ± 4.2 | 12.3 ± 3.9 | 14.6 ± 4.6 | 15.3 ± 6.5 | 14.7 ± 3.5 |
| Neutrophil | 2.4 ± 0.7* | 4.4 ± 3.6 | 4.9 ± 2.9 | 4.1 ± 2.4 | 4.1 ± 3.1 | 5.0 ± 2.8 | 4.3 ± 2.2 |
| Eosinophil | 0.1 ± 0.08* | 0.07 ± 0.04† | 0.04 ± 0.03 | 0.2 ± 0.09‡ | 0.05 ± 0.03 | 0.05 ± 0.04 | 0.04 ± 0.04 |
| Basophil | 0.23 ± 0.1 | 0.2 ± 0.1 | 0.28 ± 0.7 | 0.8 ± 0.7 | 0.5 ± 0.4 | 0.4 ± 0.4 | 0.3 ± 0.3 |
| Monocytes | 1.1 ± 0.4 | 1.2 ± 0.5 | 1.2 ± 0.5 | 0.9 ± 0.3§ | 1.4 ± 0.6 | 1.5 ± 0.6 | 1.28 ± 1.0 |
| Lymphocytes | 12 ± 3.7* | 7.8 ± 3.9 | 7.9 ± 4.4 | 6.7 ± 2.3‖ | 8.4 ± 3.7 | 8.5 ± 4.2 | 9.0 ± 3.0 |
| . | Day 0 . | Day 14 . | Day 21 . | Day 28 . | |||
|---|---|---|---|---|---|---|---|
| Normal . | rIL-5 Rx . | Control . | rIL-5 Rx . | Control . | rIL-5 Rx . | Control . | |
| WBC count | 12.8 ± 4 | 14.1 ± 4.1 | 13.6 ± 4.2 | 12.3 ± 3.9 | 14.6 ± 4.6 | 15.3 ± 6.5 | 14.7 ± 3.5 |
| Neutrophil | 2.4 ± 0.7* | 4.4 ± 3.6 | 4.9 ± 2.9 | 4.1 ± 2.4 | 4.1 ± 3.1 | 5.0 ± 2.8 | 4.3 ± 2.2 |
| Eosinophil | 0.1 ± 0.08* | 0.07 ± 0.04† | 0.04 ± 0.03 | 0.2 ± 0.09‡ | 0.05 ± 0.03 | 0.05 ± 0.04 | 0.04 ± 0.04 |
| Basophil | 0.23 ± 0.1 | 0.2 ± 0.1 | 0.28 ± 0.7 | 0.8 ± 0.7 | 0.5 ± 0.4 | 0.4 ± 0.4 | 0.3 ± 0.3 |
| Monocytes | 1.1 ± 0.4 | 1.2 ± 0.5 | 1.2 ± 0.5 | 0.9 ± 0.3§ | 1.4 ± 0.6 | 1.5 ± 0.6 | 1.28 ± 1.0 |
| Lymphocytes | 12 ± 3.7* | 7.8 ± 3.9 | 7.9 ± 4.4 | 6.7 ± 2.3‖ | 8.4 ± 3.7 | 8.5 ± 4.2 | 9.0 ± 3.0 |
Data are expressed as 106 cells/mL (n = 5/group).
WBC indicates white blood cell.
Blood counts before immunization were significantly different (P < .05) from all controls at days 14, 21, and 28 after induction of EAN with PNM/CFA.
IL-5–treated animals significantly different from controls, P = .004.
IL-5–treated animals significantly different from controls, P < .001.
IL-5–treated animals significantly different from controls, P = .04.
IL-5–treated animals significantly different from controls, P = .02.