Active miRNA families in GMPs
| . | Fold enrichment* . | P* . | No. of transcripts regulated . | No. of regulated transcripts linked to lineage-affiliated signatures . |
|---|---|---|---|---|
| let-7b/c/d/e/g/i | 1.84 | 2.452 × 10−03 | 55 | 9 (16.4%) |
| miR-10a | 2.42 | 1.388 × 10−02 | 16 | 3 (18.8%) |
| miR-15/16/195 | 1.65 | 1.032 × 10−02 | 57 | 8 (14%) |
| miR-17/20/93/106 | 2.82 | 2.787 × 10−10 | 83 | 15 (18.1%) |
| miR-19a/b | 1.93 | 6.528 × 10−04 | 60 | 15 (25%) |
| miR-25/92 | 2.37 | 1.657 × 10−05 | 54 | 12 (22.2%) |
| miR-26a/b | 1.80 | 8.623 × 10−03 | 45 | 10 (22.2%) |
| miR-27a/b | 1.79 | 2.452 × 10−03 | 59 | 12 (20.3%) |
| miR-30a/b/d/e | 1.82 | 1.073 × 10−03 | 69 | 14 (20.3%) |
| miR-130b/301a | 1.64 | 2.679 × 10−02 | 42 | 8 (19%) |
| miR-142-3p | 4.02 | 2.073 × 10−08 | 36 | 10 (27.8%) |
| miR-181a/c | 1.71 | 9.031 × 10−03 | 52 | 14 (26.9%) |
| miR-200c | 1.68 | 9.828 × 10−03 | 53 | 9 (17%) |
| miR-203 | 1.86 | 1.388 × 10−02 | 33 | 5 (15.2%) |
| miR-222 | 2.30 | 9.025 × 10−03 | 21 | 5 (23.8%) |
| miR-223 | 2.19 | 2.547 × 10−02 | 17 | 4 (23.5%) |
| miR-320 | 2.27 | 4.134 × 10−04 | 42 | 5 (11.9%) |
| miR-340-5p | 1.82 | 1.525 × 10−03 | 64 | 7 (10.9%) |
| miR-494 | 2.35 | 4.099 × 10−03 | 24 | 5 (20.8%) |
| miR-503 | 2.23 | 9.025 × 10−03 | 23 | 2 (8.7%) |
| . | Fold enrichment* . | P* . | No. of transcripts regulated . | No. of regulated transcripts linked to lineage-affiliated signatures . |
|---|---|---|---|---|
| let-7b/c/d/e/g/i | 1.84 | 2.452 × 10−03 | 55 | 9 (16.4%) |
| miR-10a | 2.42 | 1.388 × 10−02 | 16 | 3 (18.8%) |
| miR-15/16/195 | 1.65 | 1.032 × 10−02 | 57 | 8 (14%) |
| miR-17/20/93/106 | 2.82 | 2.787 × 10−10 | 83 | 15 (18.1%) |
| miR-19a/b | 1.93 | 6.528 × 10−04 | 60 | 15 (25%) |
| miR-25/92 | 2.37 | 1.657 × 10−05 | 54 | 12 (22.2%) |
| miR-26a/b | 1.80 | 8.623 × 10−03 | 45 | 10 (22.2%) |
| miR-27a/b | 1.79 | 2.452 × 10−03 | 59 | 12 (20.3%) |
| miR-30a/b/d/e | 1.82 | 1.073 × 10−03 | 69 | 14 (20.3%) |
| miR-130b/301a | 1.64 | 2.679 × 10−02 | 42 | 8 (19%) |
| miR-142-3p | 4.02 | 2.073 × 10−08 | 36 | 10 (27.8%) |
| miR-181a/c | 1.71 | 9.031 × 10−03 | 52 | 14 (26.9%) |
| miR-200c | 1.68 | 9.828 × 10−03 | 53 | 9 (17%) |
| miR-203 | 1.86 | 1.388 × 10−02 | 33 | 5 (15.2%) |
| miR-222 | 2.30 | 9.025 × 10−03 | 21 | 5 (23.8%) |
| miR-223 | 2.19 | 2.547 × 10−02 | 17 | 4 (23.5%) |
| miR-320 | 2.27 | 4.134 × 10−04 | 42 | 5 (11.9%) |
| miR-340-5p | 1.82 | 1.525 × 10−03 | 64 | 7 (10.9%) |
| miR-494 | 2.35 | 4.099 × 10−03 | 24 | 5 (20.8%) |
| miR-503 | 2.23 | 9.025 × 10−03 | 23 | 2 (8.7%) |
The fold enrichment and FDR-corrected P values of predicted targets in the fraction that are significantly up-regulated in DicerΔ/Δ cells compared with the nonregulated targets. Only the significant results (P < .05) of the miRNAs that are expressed in GMPs are shown. The lineage-affiliated signatures are shown in supplemental Table 4.