Table 2 Frequency of splicing factor... | American Society of Hematology

Table 2

Frequency of splicing factor mutations in MPNs, AML derived from MPNs, de novo AML, and AML derived from MDSs

Disease	Mutational frequency, %
Disease	SF3B1	U2AF1	ZRSR2	SRSF2
Primary myelofibrosis (n = 38)	5.3	2.6	5.6	2.6
De novo AML (n = 54)	3.7	1.9	5.6	5.6
Secondary AML from MDS (n = 42)	4.8	9.5	2.4	4.8
MPNs that later transformed to AML (n = 17)	0	0	0	11.8
Secondary AML from MPNs (n = 53)	3.8	5.7	1.8	18.9*

Disease	Mutational frequency, %
Disease	SF3B1	U2AF1	ZRSR2	SRSF2
Primary myelofibrosis (n = 38)	5.3	2.6	5.6	2.6
De novo AML (n = 54)	3.7	1.9	5.6	5.6
Secondary AML from MDS (n = 42)	4.8	9.5	2.4	4.8
MPNs that later transformed to AML (n = 17)	0	0	0	11.8
Secondary AML from MPNs (n = 53)	3.8	5.7	1.8	18.9*

P < .05 compared with frequency in all other disease (2-tailed, Fisher exact test).