Table 1

Clinical characteristics of overt strokes and silent cerebral infarcts in sickle cell anemia

Overt strokesSilent cerebral infarcts
Frequency prior to 6th birthday 2%-5% 27% 
Mean global IQ 71 83 
Primary prevention Transcranial Doppler followed by blood transfusion therapy None established; ongoing limited institution studies of hydroxyurea and HLA-matched sibling transplantation 
Secondary prevention Blood transfusion therapy HLA-matched sibling transplant revascularization for moyamoya None established; await the results of the Silent Cerebral Infarct Transfusion Trial 
Overt strokesSilent cerebral infarcts
Frequency prior to 6th birthday 2%-5% 27% 
Mean global IQ 71 83 
Primary prevention Transcranial Doppler followed by blood transfusion therapy None established; ongoing limited institution studies of hydroxyurea and HLA-matched sibling transplantation 
Secondary prevention Blood transfusion therapy HLA-matched sibling transplant revascularization for moyamoya None established; await the results of the Silent Cerebral Infarct Transfusion Trial 
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