Table 3

Treatment administration

Treatment administration
Median no. of cycles administered (range) 7 (1-40) 
Total number of cycles administered 400 
Lenalidomide  
    Number of cycles administered 400 
    Median % of targeted dose (range) 67 (3.2-100) 
    No. of patients with dose reduction (%) 20 (57) 
        Total reductions 25 
    Reasons for reductions  
        Hematologic adverse event 
        Dermatology/skin/rash 
        Infection 
        Other 
Cyclophosphamide  
    No. of cycles administered 268 
    Median % of targeted dose (%) 97 (0-108.3) 
    No. of patients with dose reduction (%) 20 (57) 
        Total reductions 28 
    Reasons for reductions  
        Hematologic adverse event 16 
        Renal 
        Infection 
        Other 
Dexamethasone  
    No. of cycles administered 384 
    Median % of targeted dose (range) 75 (0-100) 
    No. of patients with dose reduction (%) 21 (60) 
        Total reductions 44 
    Reasons for reductions  
        Gastrointestinal 
        Edema 
        Weakness 
        Confusion/mood alteration 
        Other 24 
Treatment administration
Median no. of cycles administered (range) 7 (1-40) 
Total number of cycles administered 400 
Lenalidomide  
    Number of cycles administered 400 
    Median % of targeted dose (range) 67 (3.2-100) 
    No. of patients with dose reduction (%) 20 (57) 
        Total reductions 25 
    Reasons for reductions  
        Hematologic adverse event 
        Dermatology/skin/rash 
        Infection 
        Other 
Cyclophosphamide  
    No. of cycles administered 268 
    Median % of targeted dose (%) 97 (0-108.3) 
    No. of patients with dose reduction (%) 20 (57) 
        Total reductions 28 
    Reasons for reductions  
        Hematologic adverse event 16 
        Renal 
        Infection 
        Other 
Dexamethasone  
    No. of cycles administered 384 
    Median % of targeted dose (range) 75 (0-100) 
    No. of patients with dose reduction (%) 21 (60) 
        Total reductions 44 
    Reasons for reductions  
        Gastrointestinal 
        Edema 
        Weakness 
        Confusion/mood alteration 
        Other 24 
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