Table 4 HIV proviral DNA in cases and... | American Society of Hematology

Table 4

HIV proviral DNA in cases and LTNPs/ECs

Patient groups	HIV DNA qualitative PCR			Total HIV DNA* (PBMCs)	Integrated HIV DNA* (PBMCs)	Total HIV DNA†		HIC (PBMCs)
Patient groups	PBMC	Colon	Ileum	Total HIV DNA* (PBMCs)	Integrated HIV DNA* (PBMCs)	Colon	Ileum	HIC (PBMCs)
Cases
1	Undetectable	NA	NA	6.56	0.02	NA	NA	< 0.0041
2	Gag−, Env−, LTR+	Gag−, Env−, LTR+	Gag−, Env−, LTR+	25.2	2.47	2.8	NA	< 0.0018
3	Gag−, Env−, LTR+	Gag−, Env−, LTR+	Gag+, Env+, LTR+	NA	NA	1.95	NA	0.046
4	Undetectable	Undetectable	Undetectable	Undetectable	Undetectable	< 2.6	42.4	< 0.0042
Median				6.56	0.02			0.0041
LTNPs/ECs
4	Gag+, Env−, LTR+	Gag+, Env−, LTR−		3084.48	0.42	NA	NA	0.0114
58	Gag+, Env−, LTR+			506.49	18.8	NA	NA	< 0.0058
71	Gag−, Env−, LTR+	Gag−, Env+, LTR+		14 498.24	3.24	NA	NA	0.0236
73	Undetectable	Undetectable		323.03	2.27	NA	NA	0.008
75	Gag+, Env+, LTR+			235.42	51.95	NA	NA	0.289
84	Gag+, Env−, LTR+	Gag−, Env+, LTR−		179.80	74	NA	NA	0.0288
86	Gag+, Env+, LTR+			153.33	3.71	NA	NA	0.0223
88	Gag−, Env−, LTR+	Gag−, Env−, LTR+	Gag−, Env−, LTR+	61.24	16.97	1255.46	NA	0.026
96	Gag+, Env−, LTR+	Gag+, Env−, LTR+		2576.66	7.39	NA	NA	NA
37	Gag+, Env+, LTR+			201.51	9.77	NA	NA	NA
17	Gag+, Env−, LTR+	Gag+, Env−, LTR+		668.93	29.45	NA	NA	NA
Median				323‡	9.77‡	NA	NA	0.023

Patient groups	HIV DNA qualitative PCR			Total HIV DNA* (PBMCs)	Integrated HIV DNA* (PBMCs)	Total HIV DNA†		HIC (PBMCs)
Patient groups	PBMC	Colon	Ileum	Total HIV DNA* (PBMCs)	Integrated HIV DNA* (PBMCs)	Colon	Ileum	HIC (PBMCs)
Cases
1	Undetectable	NA	NA	6.56	0.02	NA	NA	< 0.0041
2	Gag−, Env−, LTR+	Gag−, Env−, LTR+	Gag−, Env−, LTR+	25.2	2.47	2.8	NA	< 0.0018
3	Gag−, Env−, LTR+	Gag−, Env−, LTR+	Gag+, Env+, LTR+	NA	NA	1.95	NA	0.046
4	Undetectable	Undetectable	Undetectable	Undetectable	Undetectable	< 2.6	42.4	< 0.0042
Median				6.56	0.02			0.0041
LTNPs/ECs
4	Gag+, Env−, LTR+	Gag+, Env−, LTR−		3084.48	0.42	NA	NA	0.0114
58	Gag+, Env−, LTR+			506.49	18.8	NA	NA	< 0.0058
71	Gag−, Env−, LTR+	Gag−, Env+, LTR+		14 498.24	3.24	NA	NA	0.0236
73	Undetectable	Undetectable		323.03	2.27	NA	NA	0.008
75	Gag+, Env+, LTR+			235.42	51.95	NA	NA	0.289
84	Gag+, Env−, LTR+	Gag−, Env+, LTR−		179.80	74	NA	NA	0.0288
86	Gag+, Env+, LTR+			153.33	3.71	NA	NA	0.0223
88	Gag−, Env−, LTR+	Gag−, Env−, LTR+	Gag−, Env−, LTR+	61.24	16.97	1255.46	NA	0.026
96	Gag+, Env−, LTR+	Gag+, Env−, LTR+		2576.66	7.39	NA	NA	NA
37	Gag+, Env+, LTR+			201.51	9.77	NA	NA	NA
17	Gag+, Env−, LTR+	Gag+, Env−, LTR+		668.93	29.45	NA	NA	NA
Median				323‡	9.77‡	NA	NA	0.023

HIC indicates high input quantitative coculture assay, measuring infectious units per 10⁶ (IUPM) CD4⁺ T cells; NA, not available; Env, envelope; and LTR, long terminal repeat regions of HIV-1.

Copies/10⁶ PBMCs.

†

Copies/10⁶ CD4⁺ T cells.

‡

P < .05, cases versus LTNPs/ECs.

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